R
Rachael M. Lane
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 18
Citations - 1816
Rachael M. Lane is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Platelet & Intrinsic apoptosis. The author has an hindex of 11, co-authored 17 publications receiving 1296 citations. Previous affiliations of Rachael M. Lane include Monash University, Clayton campus & University of Melbourne.
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Journal ArticleDOI
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White,Michael J. White,Kate McArthur,Kate McArthur,Donald Metcalf,Donald Metcalf,Rachael M. Lane,John C. Cambier,Marco J Herold,Marco J Herold,Mark F. van Delft,Mark F. van Delft,Sammy Bedoui,Guillaume Lessene,Guillaume Lessene,Matthew E. Ritchie,Matthew E. Ritchie,David C.S. Huang,David C.S. Huang,Benjamin T. Kile,Benjamin T. Kile +20 more
TL;DR: The apoptotic caspase cascade functions to render mitochondrial apoptosis immunologically silent, and suppresses type I interferon (IFN) production by cells undergoing Bak/Bax-mediated apoptosis.
Journal ArticleDOI
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Kate McArthur,Kate McArthur,Kate McArthur,Lachlan Whitehead,Lachlan Whitehead,John M. Heddleston,Lucy Li,Benjamin S. Padman,Viola Oorschot,Niall D. Geoghegan,Niall D. Geoghegan,Stephane Chappaz,Stephane Chappaz,Stephane Chappaz,Sophia Davidson,Hui San Chin,Rachael M. Lane,Marija Dramicanin,Marija Dramicanin,Tahnee L. Saunders,Canny Sugiana,Romina Lessene,Romina Lessene,Laura D. Osellame,Teng Leong Chew,Grant Dewson,Grant Dewson,Michael Lazarou,Georg Ramm,Guillaume Lessene,Guillaume Lessene,Michael T. Ryan,Kelly L. Rogers,Kelly L. Rogers,Mark F. van Delft,Mark F. van Delft,Benjamin T. Kile,Benjamin T. Kile,Benjamin T. Kile +38 more
TL;DR: This study provides a mechanistic description of mtDNA release from mitochondria during apoptosis, and suggests that mtDNA is found outside the mitochondria—and, indeed, outside the cell—in a wide range of circumstances.
Journal ArticleDOI
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
Emma C. Josefsson,Chloé James,Katya J. Henley,Marlyse A. Debrincat,Marlyse A. Debrincat,Kelly L. Rogers,Kelly L. Rogers,Mark R. Dowling,Mark R. Dowling,Michael J. White,Michael J. White,Elizabeth A. Kruse,Elizabeth A. Kruse,Rachael M. Lane,Sarah Ellis,Paquita Nurden,Kylie D. Mason,Kylie D. Mason,Lorraine A. O'Reilly,Lorraine A. O'Reilly,Andrew W. Roberts,Andrew W. Roberts,Donald Metcalf,Donald Metcalf,David C.S. Huang,David C.S. Huang,Benjamin T. Kile,Benjamin T. Kile +27 more
TL;DR: Deletion of Bak and Bax, the effectors of mitochondrial apoptosis, does not affect platelet production, however, loss of prosurvival Bcl-xL results in megakaryocyte apoptosis and failure of platelet shedding.
Journal ArticleDOI
IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.
Andrew J. Murphy,Andrew J. Murphy,Michael J Kraakman,Helene L. Kammoun,Dragana Dragoljevic,Dragana Dragoljevic,Man K.S. Lee,Man K.S. Lee,Kate E. Lawlor,Kate E. Lawlor,John M. Wentworth,John M. Wentworth,Ajithkumarx Vasanthakumar,Ajithkumarx Vasanthakumar,Motti Gerlic,Lachlan Whitehead,Ladina DiRago,Louise H. Cengia,Rachael M. Lane,Donald Metcalf,Donald Metcalf,James E Vince,James E Vince,Leonard C. Harrison,Leonard C. Harrison,Axel Kallies,Axel Kallies,Benjamin T. Kile,Benjamin T. Kile,Ben A. Croker,Mark A. Febbraio,Mark A. Febbraio,Seth L. Masters,Seth L. Masters +33 more
TL;DR: NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18, preventing obesity and metabolic syndrome.
Journal ArticleDOI
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
Marlyse A. Debrincat,Marlyse A. Debrincat,Emma C. Josefsson,Emma C. Josefsson,Chloé James,Chloé James,Katya J. Henley,Sarah Ellis,Marion Lebois,Kelly L. Betterman,Rachael M. Lane,Kelly L. Rogers,Michael J. White,Michael J. White,Andrew W. Roberts,Andrew W. Roberts,Natasha L. Harvey,Natasha L. Harvey,Donald Metcalf,Donald Metcalf,Benjamin T. Kile,Benjamin T. Kile +21 more
TL;DR: The studies indicate that the combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage.