R
Rachael N. McVicar
Researcher at Discovery Institute
Publications - 13
Citations - 1121
Rachael N. McVicar is an academic researcher from Discovery Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 7 publications receiving 532 citations.
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Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Charlotte B Spliid,Charlotte B Spliid,Jessica Pihl,Jessica Pihl,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,Elizabeth M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sumit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +42 more
TL;DR: A model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2 is suggested, in which Manipulation of hepara sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,E. M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Gordts, Plsm, Chanda, S. K.,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +34 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain and may represent new therapeutic opportunities for exogenous heparin.
Journal ArticleDOI
Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.
Robert T. Schooley,Aaron F. Carlin,James R. Beadle,Nadejda Valiaeva,Xing-Quan Zhang,Alex E. Clark,Rachel E McMillan,Sandra L Leibel,Rachael N. McVicar,Jialei Xie,Aaron F. Garretson,Victoria I Smith,Joyce Murphy,Karl Y. Hostetler +13 more
TL;DR: In this article, a simple, orally bioavailable lipid analogs of remdesivir nucleoside (RVn) were processed to RVn monophosphate by a single-step intracellular cleavage.
Journal ArticleDOI
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation.
Sandra L Leibel,Sandra L Leibel,Rachael N. McVicar,Alicia M. Winquist,Walter D. Niles,Evan Y. Snyder,Evan Y. Snyder +6 more
TL;DR: A system that allows human embryonic stem cells and induced pluripotent stem cells to differentiate and form three‐dimensional structures that emulate the development, cytoarchitecture, and function of the lung are described, containing epithelial and mesenchymal cell populations and including the production of surfactant and presence of ciliated cells.
Posted ContentDOI
Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs.
Robert T. Schooley,Aaron F. Carlin,James R. Beadle,Nadejda Valiaeva,Xing-Quan Zhang,Alex E. Clark,Rachel E McMillan,Sandra L Leibel,Rachael N. McVicar,Jialei Xie,Aaron F. Garretson,Victoria I Smith,Joyce Murphy,Karl Y. Hostetler +13 more
TL;DR: In this paper, the authors focused on making simple, orally bioavailable lipid analogs of Remdesivir nucleoside (RVn, GS-441524) that are processed to RVn-monophosphate, the precursor of the active RVn triphosphate by a single-step intracellular cleavage.