J
Jessica Pihl
Researcher at University of California, San Diego
Publications - 6
Citations - 950
Jessica Pihl is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Heparan sulfate & Heparin. The author has an hindex of 5, co-authored 5 publications receiving 420 citations. Previous affiliations of Jessica Pihl include University of California, Berkeley & University of Copenhagen.
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Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Charlotte B Spliid,Charlotte B Spliid,Jessica Pihl,Jessica Pihl,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,Elizabeth M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sumit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +42 more
TL;DR: A model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2 is suggested, in which Manipulation of hepara sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
Journal ArticleDOI
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Shuofeng Yuan,Shuofeng Yuan,Xin Yin,Xin Yin,Xiangzhi Meng,Jasper Fuk-Woo Chan,Zi-Wei Ye,Laura Riva,Laura Riva,Lars Pache,Chris Chun-Yiu Chan,Pok Man Lai,Chris Chung-Sing Chan,Vincent Kwok-Man Poon,Andrew Chak-Yiu Lee,Naoko Matsunaga,Yuan Pu,Chun-Kit Yuen,Jianli Cao,Ronghui Liang,Kaiming Tang,Li Sheng,Li Sheng,Yushen Du,Wan Xu,Chit-Ying Lau,Ko-Yung Sit,Wing-Kuk Au,Runming Wang,Yu-Yuan Zhang,Yan-Dong Tang,Thomas Mandel Clausen,Thomas Mandel Clausen,Jessica Pihl,Jessica Pihl,Juntaek Oh,Juntaek Oh,Kong-Hung Sze,Anna Jinxia Zhang,Hin Chu,Kin-Hang Kok,Dong Wang,Dong Wang,Xue-Hui Cai,Jeffrey D. Esko,Ivan Hung,Ronald A. Li,Honglin Chen,Hongzhe Sun,Dong-Yan Jin,Ren Sun,Ren Sun,Sumit K. Chanda,Kwok-Yung Yuen +53 more
TL;DR: In this paper, the authors show that clofazimine-an anti-leprosy drug with a favorable safety profile-possesses inhibitory activity against several coronaviruses, and can antagonize the replication of SARS-CoV-2 and MERS-coV in a range of in vitro systems.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B. Spliid,Charlotte B. Spliid,Jessica Pihl,Jessica Pihl,Chelsea D. Painter,Chelsea D. Painter,Bryan E. Thacker,Charles A. Glass,Anoop Narayanan,Sydney A. Majowicz,Yang Zhang,Jonathan L. Torres,Gregory J. Golden,Gregory J. Golden,Ryan Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Benjamin P. Kellman,Cameron Martino,Cameron Martino,Philip L.S.M. Gordts,Sandra L Leibel,Summit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +39 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain, and docking studies suggest a putative heparin/heparin sulfate-binding site adjacent to the domain that binds to ACE2.
Journal ArticleDOI
Bacteria-Inspired Nanomedicine.
Maya Holay,Zhongyuan Guo,Jessica Pihl,Jiyoung Heo,Joon Ho Park,Ronnie H. Fang,Liangfang Zhang +6 more
TL;DR: Bacterial derivatives such as membrane ghosts, extracellular vesicles, spores, and toxins have proven advantageous for use in nanotherapeutic applications, as they preserve many of the features from the original bacteria while also offering distinct advantages.
Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B. Spliid,Jessica Pihl,Chelsea D. Painter,Bryan E. Thacker,Charles A. Glass,Anoop Narayanan,Sydney A. Majowicz,Yang Zhang,Jonathan L. Torres,Gregory J. Golden,Ryan Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sandra L Leibel,Summit K. Chanda,Aaron G. Schmidt,Kamil Godula,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +31 more
TL;DR: In this article, the authors show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain.