A
Aaron F. Garretson
Researcher at University of California, San Diego
Publications - Â 18
Citations - Â 1334
Aaron F. Garretson is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Heparan sulfate. The author has an hindex of 6, co-authored 11 publications receiving 607 citations. Previous affiliations of Aaron F. Garretson include Columbia University & University of California, Berkeley.
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Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Charlotte B Spliid,Charlotte B Spliid,Jessica Pihl,Jessica Pihl,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,Elizabeth M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sumit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +42 more
TL;DR: A model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2 is suggested, in which Manipulation of hepara sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,E. M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Gordts, Plsm, Chanda, S. K.,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +34 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain and may represent new therapeutic opportunities for exogenous heparin.
Posted ContentDOI
Virologic and Immunologic Characterization of COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment
Aaron F. Carlin,Alex E. Clark,Antoine Chaillon,Aaron F. Garretson,W. Bray,Magali Porrachi,Asherlev T Santos,Davey M. Smith +7 more
TL;DR: It was found that neither NM resistance nor absence of neutralizing immunity were likely causes of the recrudescence.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B. Spliid,Charlotte B. Spliid,Jessica Pihl,Jessica Pihl,Chelsea D. Painter,Chelsea D. Painter,Bryan E. Thacker,Charles A. Glass,Anoop Narayanan,Sydney A. Majowicz,Yang Zhang,Jonathan L. Torres,Gregory J. Golden,Gregory J. Golden,Ryan Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Benjamin P. Kellman,Cameron Martino,Cameron Martino,Philip L.S.M. Gordts,Sandra L Leibel,Summit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +39 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain, and docking studies suggest a putative heparin/heparin sulfate-binding site adjacent to the domain that binds to ACE2.
Journal ArticleDOI
Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.
Robert T. Schooley,Aaron F. Carlin,James R. Beadle,Nadejda Valiaeva,Xing-Quan Zhang,Alex E. Clark,Rachel E McMillan,Sandra L Leibel,Rachael N. McVicar,Jialei Xie,Aaron F. Garretson,Victoria I Smith,Joyce Murphy,Karl Y. Hostetler +13 more
TL;DR: In this article, a simple, orally bioavailable lipid analogs of remdesivir nucleoside (RVn) were processed to RVn monophosphate by a single-step intracellular cleavage.