R
Raju Tomer
Researcher at Columbia University
Publications - 45
Citations - 4660
Raju Tomer is an academic researcher from Columbia University. The author has contributed to research in topics: Light sheet fluorescence microscopy & Microscopy. The author has an hindex of 24, co-authored 40 publications receiving 3887 citations. Previous affiliations of Raju Tomer include Stanford University & Indian Institutes of Technology.
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Advanced CLARITY for rapid and high-resolution imaging of intact tissues
TL;DR: Protocols spanning multiple dimensions of the CLARITY workflow are described, ranging from simple, reliable and efficient lipid removal without electrophoretic instrumentation to optimized objectives and integration with light-sheet optics (CLARITY-optimized light- sheet microscopy (COLM)) for accelerating data collection from clarified samples by several orders of magnitude while maintaining or increasing quality and resolution.
Journal ArticleDOI
Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits.
Talia N. Lerner,Carrie Shilyansky,Thomas J. Davidson,Kathryn E. Evans,Kevin T. Beier,Kelly A. Zalocusky,Ailey K. Crow,Robert C. Malenka,Liqun Luo,Raju Tomer,Karl Deisseroth +10 more
TL;DR: Two parallel nigrostriatal dopamine neuron subpopulations differing in biophysical properties, input wiring, output wiring to dorsomedial striatum versus dorsolateral striatum (DLS), and natural activity patterns during free behavior are identified.
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Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy.
TL;DR: This work developed one-photon and multiphoton SiMView implementations and recorded cellular dynamics in entire Drosophila melanogaster embryos with 30-s temporal resolution throughout development and performed high-resolution long-term imaging of the developing nervous system and followed neuroblast cell lineages in vivo.
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Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Roman A. Romanov,Amit Zeisel,Joanne Bakker,Fatima Girach,Arash Hellysaz,Raju Tomer,Alán Alpár,Alán Alpár,Jan Mulder,Frédéric Clotman,Erik Keimpema,Brian Hsueh,Ailey K. Crow,Henrik Martens,Christian Schwindling,Daniela Calvigioni,Daniela Calvigioni,Jaideep S. Bains,Zoltán Máté,Gábor Szabó,Yuchio Yanagawa,Ming-Dong Zhang,André F. Rendeiro,Matthias Farlik,Mathias Uhlén,Peer Wulff,Christoph Bock,Christian Broberger,Karl Deisseroth,Tomas Hökfelt,Sten Linnarsson,Tamas L. Horvath,Tibor Harkany,Tibor Harkany +33 more
TL;DR: A catalog of neuronal subclasses provides new understanding of hypothalamic organization and function and distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching.
Journal ArticleDOI
Ancient animal microRNAs and the evolution of tissue identity
Foteini Christodoulou,Florian Raible,Raju Tomer,Oleg Simakov,Kalliopi Trachana,Sebastian Klaus,Heidi Snyman,Gregory J. Hannon,Peer Bork,Detlev Arendt +9 more
TL;DR: Findings reveal that microRNA evolution and the establishment of tissue identities were closely coupled in bilaterian evolution, and outline a minimum set of cell types and tissues that existed in the protostome–deuterostome ancestor.