R
Raju Tomer
Researcher at Columbia University
Publications - 45
Citations - 4660
Raju Tomer is an academic researcher from Columbia University. The author has contributed to research in topics: Light sheet fluorescence microscopy & Microscopy. The author has an hindex of 24, co-authored 40 publications receiving 3887 citations. Previous affiliations of Raju Tomer include Stanford University & Indian Institutes of Technology.
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CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions.
Yi Feng,Yi Feng,Peng Cui,Peng Cui,Xiaowei Lu,Brian Hsueh,Fredrik Möller Billig,Yanez Livia Zarnescu,Raju Tomer,Derek Boerboom,Peter Carmeliet,Karl Deisseroth,Aaron J. W. Hsueh +12 more
TL;DR: The CLARITY approach uncovers unique features of ovarian architecture and essential roles of vasculature in organizing follicles to allow future studies on normal and diseased human ovaries, and could also reveal roles of neo-angiogenesis during embryonic development and tumorigenesis.
Journal ArticleDOI
Shedding light on the system: studying embryonic development with light sheet microscopy.
TL;DR: An overview of the different basic implementations of LSFM is provided, recent technical advances in the field are reviewed and applications in the context of embryonic development are highlighted with a discussion of promising future directions.
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Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder
Job O. de Jong,Ceyda Llapashtica,Matthieu Genestine,Kevin A. Strauss,Frank A. Provenzano,Yan Sun,Huixiang Zhu,Giuseppe P. Cortese,Francesco Gavino Brundu,Karlla W. Brigatti,Barbara Corneo,Bianca Migliori,Raju Tomer,Steven A. Kushner,Steven A. Kushner,Christoph Kellendonk,Jonathan A. Javitch,Bin Xu,Sander Markx +18 more
TL;DR: In this article, the authors used forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of autism spectrum disorder (ASD) with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development.
Journal ArticleDOI
Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin
Sean J. Miller,Thomas Philips,Namho Kim,Namho Kim,Raha Dastgheyb,Zhuoxun Chen,Yi Chun Hsieh,J. Gavin Daigle,Malika S Datta,Jeannie Chew,Svetlana Vidensky,Jacqueline T. Pham,Ethan G. Hughes,Michael B. Robinson,Michael B. Robinson,Rita Sattler,Raju Tomer,Jung Soo Suk,Jung Soo Suk,Dwight E. Bergles,Norman J. Haughey,Mikhail V. Pletnikov,Justin Hanes,Justin Hanes,Jeffrey D. Rothstein +24 more
TL;DR: Evidence is provided that human and rodent astroglia subtypes are regionally and functionally distinct, can regulate local neuronal dendrite and synaptic spine development, and contribute to disease.
Light sheet theta microscopy for rapid high-resolution imaging of large biological samples
Bianca Migliori,Malika S Datta,Christophe Dupre,Mehmet C Apak,Ola Hermanson,Rafael Yuste,Raju Tomer,Edward S. Boyden,Shoh Asano,Ruixuan Gao,Edward S. Boyden +10 more
TL;DR: The reported LSTM approach is a significant step for the rapid high-resolution quantitative mapping of the structure and function of very large biological systems, and also for rapid volumetric calcium imaging of highly motile animals, such as Hydra, undergoing non-isomorphic body shape changes.