R
Raju Tomer
Researcher at Columbia University
Publications - 45
Citations - 4660
Raju Tomer is an academic researcher from Columbia University. The author has contributed to research in topics: Light sheet fluorescence microscopy & Microscopy. The author has an hindex of 24, co-authored 40 publications receiving 3887 citations. Previous affiliations of Raju Tomer include Stanford University & Indian Institutes of Technology.
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Journal ArticleDOI
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity
Nobuyuki Tanaka,Nobuyuki Tanaka,Shigeaki Kanatani,Raju Tomer,Cecilia Sahlgren,Cecilia Sahlgren,Pauliina Kronqvist,Dagmara Kaczynska,Lauri Louhivuori,Loránd L. Kis,Loránd L. Kis,Claes Lindh,Claes Lindh,Przemysław Mitura,Andrzej Stepulak,Sara Corvigno,Johan Hartman,Johan Hartman,Patrick Micke,Artur Mezheyeuski,Carina Strell,Joseph W. Carlson,Joseph W. Carlson,Carlos Fernández Moro,Hanna Dahlstrand,Hanna Dahlstrand,Hanna Dahlstrand,Arne Östman,Kazuhiro Matsumoto,Peter Wiklund,Mototsugu Oya,Ayako Miyakawa,Karl Deisseroth,Karl Deisseroth,Per Uhlén +34 more
TL;DR: It is shown that three-dimensional light-sheet microscopy of cleared solid tumours can identify unique patterns of phenotypic heterogeneity, in the epithelial-to-mesenchymal transition and in angiogenesis, at single-cell resolution in whole formalin-fixed paraffin-embedded (FFPE) biopsy samples.
Journal ArticleDOI
Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution
Tonmoy Chakraborty,Meghan Driscoll,Elise Jeffery,Malea M. Murphy,Philippe Roudot,Bo-Jui Chang,Saumya Vora,Wen Mai Wong,Cara D. Nielson,Hua Zhang,Vladimir Zhemkov,Chitkale Hiremath,Estanislao Daniel De La Cruz,Yating Yi,Ilya Bezprozvanny,Hu Zhao,Raju Tomer,Rainer Heintzmann,Rainer Heintzmann,Julian P. Meeks,Denise K. Marciano,Sean J. Morrison,Gaudenz Danuser,Kevin M. Dean,Reto Fiolka +24 more
TL;DR: Cleared-tissue axially swept light-sheet microscopy (ctASLM) enables high-speed, refraction index-independent imaging of live, cleared and expanded samples with isotropic, submicron resolution.
Journal ArticleDOI
Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels.
Katja Specht,Eugenia Haralambieva,Karin Bink,Marcus Kremer,Sonja Mandl-Weber,Ina Koch,Raju Tomer,Heinz Höfler,Ed Schuuring,Philip M. Kluin,Falko Fend,Leticia Quintanilla-Martinez +11 more
TL;DR: The data indicate that deregulation of MYEOV is not favored in MM and further strengthens the role of cyclin D1 overexpression in lymphoid malignancies with a t(11;14)(q13;q32) translocation.
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Development of the annelid axochord: Insights into notochord evolution
Antonella Lauri,Thibaut Brunet,Mette Handberg-Thorsager,Antje H. L. Fischer,Oleg Simakov,Patrick R. H. Steinmetz,Raju Tomer,Raju Tomer,Philipp J. Keller,Detlev Arendt,Detlev Arendt +10 more
TL;DR: Ancestral state reconstruction suggests that contractile mesodermal midline cells existed in bilaterian ancestors and it is proposed that these cells, via vacuolization and stiffening, gave rise to the chordate notochord.
Journal ArticleDOI
Light sheet theta microscopy for rapid high-resolution imaging of large biological samples
Bianca Migliori,Bianca Migliori,Malika S Datta,Christophe Dupre,Mehmet C Apak,Shoh Asano,Shoh Asano,Ruixuan Gao,Edward S. Boyden,Ola Hermanson,Rafael Yuste,Raju Tomer +11 more
TL;DR: Light sheet theta microscopy (LSTM) as mentioned in this paper was proposed to uniformly illuminate samples from the same side as the detection objective without sacrificing the imaging resolution, depth, and speed.