R
Ralph J. DiLeone
Researcher at Yale University
Publications - 115
Citations - 15894
Ralph J. DiLeone is an academic researcher from Yale University. The author has contributed to research in topics: Nucleus accumbens & Lateral hypothalamus. The author has an hindex of 55, co-authored 109 publications receiving 14363 citations. Previous affiliations of Ralph J. DiLeone include Stanford University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Neurobiology of depression.
Eric J. Nestler,Michel Barrot,Ralph J. DiLeone,Amelia J. Eisch,Stephen J. Gold,Lisa M. Monteggia +5 more
TL;DR: A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome, and advances will fundamentally improve the treatment and prevention of depression.
Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
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Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Jonathan D. Hommel,Richard Trinko,Richard Trinko,Robert M. Sears,Dan Georgescu,Zong Wu Liu,Zong Wu Liu,Xiao-Bing Gao,Jeremy J. Thurmon,Michela "Micky" Marinelli,Ralph J. DiLeone,Ralph J. DiLeone +11 more
TL;DR: It is shown that VTA dopamine neurons express Lepr mRNA and respond to leptin with activation of an intracellular JAK-STAT pathway and a reduction in firing rate and this data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on Vta dopamine neurons.
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CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
Michel Barrot,Jocelien D A Olivier,Linda I. Perrotti,Ralph J. DiLeone,Olivier Berton,Amelia J. Eisch,Soren Impey,Daniel R. Storm,Rachael L. Neve,Jerry C. P. Yin,Venetia Zachariou,Eric J. Nestler +11 more
TL;DR: It is shown that environmental stimuli regulate CRE-mediated transcription within the nucleus accumbens shell, and that changes in CREB activity within this brain area subsequently alter gating between emotional stimuli and their behavioral responses.
Journal ArticleDOI
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis.
Diane C. Lagace,Mary C. Whitman,Michele A. Noonan,Jessica L. Ables,Nathan A. DeCarolis,Amy A. Arguello,Michael H. Donovan,Stephanie J. Fischer,Laure A. Farnbauch,Robert D. Beech,Ralph J. DiLeone,Charles A. Greer,Chitra D. Mandyam,Amelia J. Eisch +13 more
TL;DR: The utility of the nestin-CreERT2/R26R-YFP mouse for inducible gene ablation in stem cells and their progeny in vivo in the two major regions of adult neurogenesis is highlighted.