R
Randall French
Researcher at University of California, San Diego
Publications - 26
Citations - 964
Randall French is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Pancreatic cancer & Tumor microenvironment. The author has an hindex of 15, co-authored 25 publications receiving 688 citations. Previous affiliations of Randall French include University of California, Berkeley.
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Journal ArticleDOI
GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets.
Paul A. Insel,Krishna Sriram,Shu Z. Wiley,Andrea Wilderman,Trishna Katakia,Thalia McCann,Hiroshi Yokouchi,Lingzhi Zhang,Ross Corriden,Dongling Liu,Michael E. Feigin,Randall French,Andrew M. Lowy,Fiona Murray +13 more
TL;DR: It is proposed that highly expressed GPCRs in cancer cells may contribute to the malignant phenotype, serve as biomarkers and/or may be novel therapeutic targets for the treatment of cancer.
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Tumor-Penetrating iRGD Peptide Inhibits Metastasis
Kazuki N. Sugahara,Kazuki N. Sugahara,Gary B. Braun,Gary B. Braun,Tatiana Hurtado de Mendoza,Venkata Ramana Kotamraju,Randall French,Andrew M. Lowy,Tambet Teesalu,Tambet Teesalu,Erkki Ruoslahti,Erkki Ruoslahti +11 more
TL;DR: It is reported that a prototypic tumor-penetrating peptide iRGD (amino acid sequence: CRGDKGPDC) potently inhibits spontaneous metastasis in mice and may provide a significant additional benefit when this peptide is used for drug delivery to tumors.
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A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.
Nikki K. Lytle,L. Paige Ferguson,Nirakar Rajbhandari,Kathryn Gilroy,Raymond G. Fox,Anagha Deshpande,Christian M. Schürch,Michael Hamilton,Neil Robertson,Wei Lin,Pawan Noel,Martin Wartenberg,Inti Zlobec,Micha Eichmann,José A. Galván,Evanthia Karamitopoulou,Tami Gilderman,Lourdes A Esparza,Yutaka Shima,Philipp Spahn,Randall French,Nathan E. Lewis,Kathleen M. Fisch,Roman Sasik,Sara Brin Rosenthal,Marcie Kritzik,Daniel D. Von Hoff,Haiyong Han,Trey Ideker,Aniruddha J. Deshpande,Andrew M. Lowy,Peter D. Adams,Peter D. Adams,Tannishtha Reya +33 more
TL;DR: RNA sequencing, chromatin immunoprecipitation, and genome-wide CRISPR analysis identify an orthogonal co-option of immuno-regulatory signals by pancreatic cancer stem cells, suggesting that autoimmune drugs should be evaluated as novel treatment strategies for Pancreatic cancer patients.
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Silencing of RON Receptor Signaling Promotes Apoptosis and Gemcitabine Sensitivity in Pancreatic Cancers
Jocelyn M. Logan-Collins,Ryan M. Thomas,Peter T. Yu,Dawn Jaquish,Evangeline Mose,Randall French,William D. Stuart,Rebecca J. McClaine,Bruce J. Aronow,Robert M. Hoffman,Susan E. Waltz,Andrew M. Lowy +11 more
TL;DR: It is demonstrated that RON signaling mediates cell survival and in vivo resistance to gemcitabine in pancreatic cancer, and mechanisms through which pancreatic cancers cells may circumvent RON-directed therapies are revealed.
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Development of an Orthotopic Model of Invasive Pancreatic Cancer in an Immunocompetent Murine Host
William W. Tseng,Daniel A. Winer,Justin A. Kenkel,Okmi Choi,Alan H. Shain,Jonathan R. Pollack,Randall French,Andrew M. Lowy,Edgar G. Engleman +8 more
TL;DR: A rapid, predictable orthotopic model of pancreatic adenocarcinoma in immunocompetent mice that mimics human pancreatic cancer with regard to genetic mutations, histologic appearance, and pattern of disease progression is developed.