R
Raymond R. Townsend
Researcher at University of Pennsylvania
Publications - 706
Citations - 47086
Raymond R. Townsend is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Blood pressure & Kidney disease. The author has an hindex of 84, co-authored 673 publications receiving 39096 citations. Previous affiliations of Raymond R. Townsend include University of Texas Medical Branch & University of California, San Francisco.
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Journal ArticleDOI
Evidence for phosphorylation of serine 753 in CFTR using a novel metal‐ion affinity resin and matrix‐assisted laser desorption mass spectrometry
David C. A. Neville,Christine R. Rozanas,Elmer M. Price,Darren B. Gruis,Alan S. Verkman,Raymond R. Townsend +5 more
TL;DR: The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an apical membrane C1− channel regulated by protein phosphorylation, which enables the selective recovery of phosphopeptides and identification of phosphorylated residues from a complex proteolytic digest.
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Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium
Matthew J. Ellis,Michael A. Gillette,Steven A. Carr,Amanda G. Paulovich,Richard D. Smith,Karin Rodland,Raymond R. Townsend,Christopher R. Kinsinger,Mehdi Mesri,Henry Rodriguez,Daniel C. Liebler +10 more
TL;DR: The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas program to illuminate the complex relationship between genomic abnormalities and cancer phenotypes.
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Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer.
Paul J. Adam,Robert Boyd,Kerry Louise Tyson,Fletcher Graham Charles,Alasdair Stamps,Lindsey Hudson,Helen R. Poyser,Nick Redpath,Matthew R. Griffiths,Graham Steers,Adrian L. Harris,Sonal Patel,Joanne Berry,Julie A. Loader,Raymond R. Townsend,Laurent Daviet,Pierre Legrain,Raj Parekh,Jonathan A Terrett +18 more
TL;DR: A proteomics process that comprehensively annotates the protein content of breast tumor cell membranes and defines the clinical relevance of such proteins, as well as the identification of protein-binding partners that elucidate potential functionality in cancer.
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Pheochromocytoma: The Expanding Genetic Differential Diagnosis
TL;DR: An overview of the known genetic syndromes that are commonly associated with pheochromocytoma is provided, recent data on the association of germline mutations in the succinate dehydrogenase gene family are examined, and guidelines for the genetic evaluation of phechromocyToma patients are suggested.
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West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H.
Kyung Min Chung,M. Kathryn Liszewski,Grant E. Nybakken,Alan E. Davis,Raymond R. Townsend,Daved H. Fremont,John P. Atkinson,Michael S. Diamond +7 more
TL;DR: Soluble and cell-surface-associated NS1 binds to and recruits the complement regulatory protein factor H, resulting in decreased complement activation in solution and attenuated deposition of C3 fragments and C5b–9 membrane attack complexes on cell surfaces.