R
Raymond R. Townsend
Researcher at University of Pennsylvania
Publications - 706
Citations - 47086
Raymond R. Townsend is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Blood pressure & Kidney disease. The author has an hindex of 84, co-authored 673 publications receiving 39096 citations. Previous affiliations of Raymond R. Townsend include University of Texas Medical Branch & University of California, San Francisco.
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Journal ArticleDOI
Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.
Jing Wang,Jing Wang,Zihao Ma,Steven A. Carr,Philipp Mertins,Hui Zhang,Zhen Zhang,Daniel W. Chan,Matthew J. Ellis,Raymond R. Townsend,Richard D. Smith,Jason E. McDermott,Xian Chen,Amanda G. Paulovich,Emily S. Boja,Mehdi Mesri,Christopher R. Kinsinger,Henry Rodriguez,Karin D. Rodland,Daniel C. Liebler,Bing Zhang,Bing Zhang +21 more
TL;DR: The results demonstrate that proteome profiling outperforms transcriptome profiling for coexpression based gene function prediction and should be integrated if not preferred in gene function and human disease studies.
Journal ArticleDOI
Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)
Ruth F. Dubin,Yongmei Li,Jiang He,Bernard G. Jaar,Radhakrishna R. Kallem,James P. Lash,Gail Makos,Sylvia E. Rosas,Elsayed Z. Soliman,Raymond R. Townsend,Wei Yang,Alan S. Go,Martin G. Keane,Christopher DeFilippi,Rakesh Mishra,Myles Wolf,Michael G. Shlipak +16 more
TL;DR: Knowledge of the determinants of hs-TnT in this cohort may guide further research on the pathology of heart disease in patients with CKD and help to stratify sub-groups of CKD patients at higher cardiovascular risk.
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An analysis of the sensitivity of proteogenomic mapping of somatic mutations and novel splicing events in cancer
Kelly V. Ruggles,Zuojian Tang,Xuya Wang,Himanshu Grover,Manor Askenazi,Jennifer Teubl,Song Cao,Michael D. McLellan,Karl R. Clauser,David L. Tabb,Philipp Mertins,Robbert J.C. Slebos,Petra Erdmann-Gilmore,Shunqiang Li,Harsha P. Gunawardena,Ling Xie,Tao Liu,Jian-Ying Zhou,Shisheng Sun,Katherine A. Hoadley,Charles M. Perou,Xian Chen,Sherri R. Davies,Christopher G. Maher,Christopher R. Kinsinger,Karen D. Rodland,Hui Zhang,Zhen Zhang,Li Ding,Raymond R. Townsend,Henry Rodriguez,Daniel W. Chan,Richard D. Smith,Daniel C. Liebler,Steven A. Carr,Samuel H. Payne,Matthew J. Ellis,David Fenyő +37 more
TL;DR: This large-scale proteogenomic integration allowed us to determine the degree to which mutations are translated and identify gaps in sequence coverage, thereby benchmarking current technology and progress toward whole cancer proteome and transcriptome analysis.
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Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
Allison C. Gates,Carlos Bernal-Mizrachi,Sharon L. Chinault,Chu Feng,Jochen G. Schneider,Trey Coleman,James P. Malone,Raymond R. Townsend,Manu V. Chakravarthy,Clay F. Semenkovich +9 more
TL;DR: It is reported that skeletal muscle respiratory uncoupling due to UCP1 expression diminishes age-related disease in three mouse models and accelerating metabolism in skeletal muscle does not appear to impact aging but may delay age- related disease.
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Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence.
TL;DR: The data indicate that there are definable molecular differences between Rahman and HM‐1:IMSS that may explain the phenotypic differences, and identify peroxiredoxin as an important component of virulence in amoebic colitis.