R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort
Ilse Gijselinck,Ilse Gijselinck,Sara Van Mossevelde,Sara Van Mossevelde,Julie van der Zee,Julie van der Zee,Anne Sieben,Stéphanie Philtjens,Stéphanie Philtjens,Bavo Heeman,Bavo Heeman,Sebastiaan Engelborghs,Mathieu Vandenbulcke,Greet De Baets,Veerle Bäumer,Veerle Bäumer,Ivy Cuijt,Ivy Cuijt,Marleen Van den Broeck,Marleen Van den Broeck,Karin Peeters,Karin Peeters,Maria Mattheijssens,Maria Mattheijssens,Frederic Rousseau,Rik Vandenberghe,Peter De Jonghe,Peter De Jonghe,Patrick Cras,Peter Paul De Deyn,Jean-Jacques Martin,Marc Cruts,Marc Cruts,Christine Van Broeckhoven,Christine Van Broeckhoven +34 more
TL;DR: TFD and ALS belong to the same disease continuum, and TBK1 LOF mutations are the third most frequent cause of clinical FTD in the Belgian clinically based patient cohort, after C9orf72 and GRN, and the second most common cause ofclinical ALS after C 9orf72.
Journal ArticleDOI
Attention to One or Two Features in Left or Right Visual Field: A Positron Emission Tomography Study
Rik Vandenberghe,John S. Duncan,Patrick Dupont,Robert Ward,Robert Ward,Jean-Baptiste Poline,Guy Bormans,Johan Michiels,Luc Mortelmans,Guy Orban +9 more
TL;DR: The behavioral efficiency with which subjects attend to multiple features of a single peripheral object is paralleled by enhanced activity in structures generally active during peripheral selective attention as well as in structures that depend on the specific direction of attention, most notably lateral frontal cortex.
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CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro
Julie van der Zee,Hazel Urwin,Sebastiaan Engelborghs,Marc Bruyland,Rik Vandenberghe,Bart Dermaut,Tim De Pooter,Karin Peeters,Patrick Santens,Peter Paul De Deyn,Elizabeth M. C. Fisher,John Collinge,Adrian M. Isaacs,Christine Van Broeckhoven +13 more
TL;DR: Overexpression of Belgian p.Gln165X in human neuroblastoma SK-N-SH cells showed the formation of large, aberrant endosomal structures that were highly similar to those observed for Danish p.Met178ValfsX2.
Journal ArticleDOI
Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease
Carlo Sala Frigerio,Pierre Lau,Evgenia Salta,Jos Tournoy,Koen Bossers,Rik Vandenberghe,Anders Wallin,Maria Bjerke,Henrik Zetterberg,Kaj Blennow,Bart De Strooper +10 more
TL;DR: The level of hsa-miR-27a-3p in CSF is reduced in patients with dementia due to AD in 2 different cohorts of subjects and provides the groundwork for further confirmation studies in larger cohorts and in other hospitals.
Journal ArticleDOI
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.
Nathalie Brouwers,Karen Nuytemans,Karen Nuytemans,Julie van der Zee,Julie van der Zee,Ilse Gijselinck,Ilse Gijselinck,Sebastiaan Engelborghs,Jessie Theuns,Jessie Theuns,Samir Kumar-Singh,Samir Kumar-Singh,Barbara A. Pickut,Philippe Pals,Bart Dermaut,Veerle Bogaerts,Veerle Bogaerts,Tim De Pooter,Tim De Pooter,Sally Serneels,Sally Serneels,Marleen Van den Broeck,Marleen Van den Broeck,Ivy Cuijt,Ivy Cuijt,Maria Mattheijssens,Maria Mattheijssens,Karin Peeters,Karin Peeters,Raphael Sciot,Jean-Jacques Martin,Patrick Cras,Patrick Santens,Rik Vandenberghe,Peter Paul De Deyn,Marc Cruts,Marc Cruts,Christine Van Broeckhoven,Christine Van Broeckhoven,Kristel Sleegers,Kristel Sleegers +40 more
TL;DR: To assess whether PGRN genetic variability contributed to other common neurodegenerative brain diseases, such as Alzheimer disease (AD) or Parkinson disease (PD), mutation data indicated that null mutations are rare in patients with AD and PD.