R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis
R M Mathew,Rik Vandenberghe,A Garcia-Merino,Tomotaka Yamamoto,J C Landolfi,Myrna R. Rosenfeld,Jeffrey E. Rossi,Brian Thiessen,E J Dropcho,Josep Dalmau +9 more
TL;DR: In young men with Ma2-encephalitis, the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2 -expressing tumor is found, and the presence of the five indicated criteria should prompt consideration of orchiectomy.
Journal ArticleDOI
Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
Ilse Gijselinck,Kristel Sleegers,Sebastiaan Engelborghs,Wim Robberecht,Jean-Jacques Martin,Rik Vandenberghe,Raphael Sciot,Bart Dermaut,Dirk Goossens,Julie van der Zee,Tim De Pooter,Jurgen Del-Favero,Patrick Santens,Peter De Jonghe,Peter Paul De Deyn,Christine Van Broeckhoven,Marc Cruts +16 more
TL;DR: In this paper, the nuclear TAR DNA binding protein (TDP-43) is deposited in ubiquitin-positive inclusions in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two clinicopathologically overlapping neurodegenerative diseases.
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Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His
J. van der Zee,Daniel Pirici,T Van Langenhove,S. Engelborghs,Rik Vandenberghe,M.M Hoffmann,Gisela Pusswald,M Van den Broeck,K. Peeters,Maria Mattheijssens,J. J. Martin,P.P. De Deyn,Marc Cruts,Dietrich Haubenberger,Samir Kumar-Singh,Alexander Zimprich,C. Van Broeckhoven +16 more
TL;DR: In 3 unrelated families with IBMPFD segregating VCP p.Arg159His, a high degree of clinical heterogeneity and variable penetrance of the 3 cardinal clinical phenotypes: inclusion body myopathy, Paget disease of bone, and frontotemporal lobar degeneration.
Journal ArticleDOI
Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study
Rik Vandenberghe,Marie Emmanuelle Riviere,Angelika Caputo,Judit Sovago,R. Paul Maguire,Martin R. Farlow,Giovanni Marotta,Raquel Sánchez-Valle,Philip Scheltens,J. Michael Ryan,Ana Graf +10 more
TL;DR: This randomized, double‐blind, placebo‐controlled, 90‐week study assessed safety, tolerability, and immunogenicity of CAD106 with/without adjuvant in patients with mild Alzheimer's disease.
Journal ArticleDOI
Distinct Clinical Characteristics of C9orf72 Expansion Carriers Compared With GRN, MAPT, and Nonmutation Carriers in a Flanders-Belgian FTLD Cohort
Tim Van Langenhove,Tim Van Langenhove,Julie van der Zee,Julie van der Zee,Ilse Gijselinck,Ilse Gijselinck,Sebastiaan Engelborghs,Rik Vandenberghe,Rik Vandenberghe,Mathieu Vandenbulcke,Mathieu Vandenbulcke,Jan De Bleecker,Anne Sieben,Jan Versijpt,Adrian Ivanoiu,Adrian Ivanoiu,Olivier Deryck,Christiana Willems,Lubina Dillen,Lubina Dillen,Stéphanie Philtjens,Stéphanie Philtjens,Githa Maes,Githa Maes,Veerle Bäumer,Veerle Bäumer,Marleen Van den Broeck,Marleen Van den Broeck,Maria Mattheijssens,Maria Mattheijssens,Karin Peeters,Karin Peeters,Jean-Jacques Martin,Jean-Jacques Martin,Alex Michotte,Patrick Santens,Peter De Jonghe,Peter De Jonghe,Patrick Cras,Peter Paul De Deyn,Marc Cruts,Marc Cruts,Christine Van Broeckhoven,Christine Van Broeckhoven +43 more
TL;DR: C9orf72 -associated FTLD most often presents with early-onset behavioral variant frontotemporal dementia with disinhibition as the prominent feature, with or without amyotrophic lateral sclerosis.