R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Premature termination codon mutations in ABCA7 contribute to Alzheimer's disease risk in Belgian patients.
Liene Bossaerts,Elisabeth Hens,Bernard Hanseeuw,Rik Vandenberghe,Patrick Cras,Peter Paul De Deyn,Sebastiaan Engelborghs,Christine Van Broeckhoven +7 more
TL;DR: In this article, the authors identified a PTC mutation in 67 AD patients (4.9%), and in 18 control individuals (1.8%) confirming the enrichment of ABCA7 PTC mutations in Belgian AD patients.
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Cognitive and Behavioral Manifestations in ALS: Beyond Motor System Involvement.
TL;DR: A review of the cognitive and behavioral manifestations commonly encountered in ALS patients with the goal of improving case-oriented management in clinical practice is presented in this article, where the authors introduce the principal ALS-FTSD subtypes and comment on their principal clinical manifestations, neuroimaging findings, neuropathological and genetic background.
Journal Article
Separation of β-amyloid binding and white matter uptake of (18)F-flutemetamol using spectral analysis.
TL;DR: The kinetic components of the β-amyloid ligand (18)F-flutemetamol binding in grey and white matter were investigated through spectral analysis, and a method developed for creation of parametric images separating grey andwhite matter uptake was developed.
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From information to follow-up: Ethical recommendations to facilitate the disclosure of amyloid PET scan results in a research setting.
Gwendolien Vanderschaeghe,Jolien Schaeverbeke,Rose Bruffaerts,Rik Vandenberghe,Kris Dierickx +4 more
TL;DR: This perspective article aims to evaluate the possible need for a modification of the available recommendations on amyloid PET scan disclosure, based on recent empirical evidence obtained within the field of amyloids PET.
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Binding of [18F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients.
Jolien Schaeverbeke,Sofie Celen,Julie Cornelis,Alicja Ronisz,Alicja Ronisz,Kim Serdons,Koen Van Laere,Dietmar Rudolf Thal,Dietmar Rudolf Thal,Thomas Tousseyn,Guy Bormans,Rik Vandenberghe +11 more
TL;DR: In vivo tau-PET tracer retention in the anterior temporal lobe of patients with semantic variant primary progressive aphasia (SV PPA) and in vitro autoradiography showed no [18F]AV1451 binding in SV PPA due to FTLD-TDP, while specific binding was present in SV ppa due to AD and PiD, the discrepancy between in vitro and in vivo findings remains to be explained.