R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Positron emission tomography, magnetic resonance imaging and proton NMR spectroscopy of white matter in multiple sclerosis.
Christiaan Schiepers,Paul Van Hecke,Rik Vandenberghe,Sylvie Van Oostende,Patrick Dupont,Philippe Demaerel,Guy Bormans,Herwig Carton +7 more
TL;DR: In stable MS, most large lesions have a relatively increased glucose utilization and decreased NAA concentration, which opens a new window on the classification of white matter lesions based on glucose utilization.
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Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.
Julie van der Zee,Tim Van Langenhove,Gabor G. Kovacs,Lubina Dillen,William Deschamps,Sebastiaan Engelborghs,Radoslav Matěj,Mathieu Vandenbulcke,Anne Sieben,Bart Dermaut,Katrien Smets,Philip Van Damme,Céline Merlin,Annelies Laureys,Marleen Van den Broeck,Maria Mattheijssens,Karin Peeters,Luisa Benussi,Giuliano Binetti,Roberta Ghidoni,Barbara Borroni,Alessandro Padovani,Silvana Archetti,Pau Pastor,Pau Pastor,Cristina Razquin,Sara Ortega-Cubero,Sara Ortega-Cubero,Isabel Hernández,Mercè Boada,Agustín Ruiz,Alexandre de Mendonça,Gabriel Miltenberger-Miltenyi,Frederico Simões do Couto,Sandro Sorbi,Benedetta Nacmias,Silvia Bagnoli,Caroline Graff,Caroline Graff,Huei Hsin Chiang,Huei Hsin Chiang,Håkan Thonberg,Robert Perneczky,Robert Perneczky,Janine Diehl-Schmid,Panagiotis Alexopoulos,Giovanni B. Frisoni,Christian Bonvicini,Matthis Synofzik,Walter Maetzler,Jennifer Müller vom Hagen,Ludger Schöls,Tobias B. Haack,Tim M. Strom,Holger Prokisch,Oriol Dols-Icardo,Jordi Clarimón,Alberto Lleó,Isabel Santana,Maria Rosário Almeida,Beatriz Santiago,Michael T. Heneka,Frank Jessen,Alfredo Ramirez,Raquel Sánchez-Valle,Albert Lladó,Ellen Gelpi,Stayko Sarafov,Ivailo Tournev,Ivailo Tournev,Albena Jordanova,Eva Parobkova,Gian Maria Fabrizi,Silvia Testi,Eric Salmon,Thomas Ströbel,Patrick Santens,Wim Robberecht,Peter De Jonghe,Jean Jacques Martin,Patrick Cras,Rik Vandenberghe,Peter Paul De Deyn,Peter Paul De Deyn,Marc Cruts,Kristel Sleegers,Christine Van Broeckhoven +86 more
TL;DR: Investigation of the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration showed that, comparable to other FTLD/ALS genes, SQ STM1 mutations are associated with TDP-43 pathology.
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A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD
Julie van der Zee,Rosa Rademakers,Sebastiaan Engelborghs,I. Gijselinck,Veerle Bogaerts,Rik Vandenberghe,Patrick Santens,Jo Caekebeke,Tim De Pooter,Karin Peeters,U. Lübke,Marleen Van den Broeck,Jean Jacques Martin,Marc Cruts,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,Bart Dermaut,Bart Dermaut +18 more
TL;DR: It is strongly suggested that the DR2-DR8 founder haplotype at 17q21 harbours a tau-negative FTLD causing mutation that is a much more frequent cause of FTLD in Belgium than MAPT mutations.
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Parcellation of parietal cortex: convergence between lesion-symptom mapping and mapping of the intact functioning brain.
TL;DR: In this paper, the authors focus on converging evidence obtained from patient lesion studies and from fMRI studies in the intact brain in humans, which has yielded novel insights into the functional segregation between the middle third of the intraparietal sulcus, the superior parietal lobule and the temporoparietal junction.
Journal ArticleDOI
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens,Nathalie Brouwers,Sebastiaan Engelborghs,Jean-Charles Lambert,Jean-Charles Lambert,Ekaterina Rogaeva,Rik Vandenberghe,Nathalie Le Bastard,Florence Pasquier,Steven Vermeulen,Jasper Van Dongen,Maria Mattheijssens,Karin Peeters,Richard Mayeux,Peter St George-Hyslop,Peter St George-Hyslop,Philippe Amouyel,Philippe Amouyel,Peter Paul De Deyn,Kristel Sleegers,Christine Van Broeckhoven +20 more
TL;DR: A new genetic risk association of AD with rare coding CLU variations that is independent of the 5' common association signal identified in the GWA studies is identified.