R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
Papers
More filters
Journal ArticleDOI
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.
Niklas Mattsson,Colin Groot,Willemijn J. Jansen,Susan M. Landau,Victor L. Villemagne,Sebastiaan Engelborghs,Mark M. Mintun,Alberto Lleó,José Luis Molinuevo,William J. Jagust,Giovanni B. Frisoni,Adrian Ivanoiu,Gaël Chételat,Catarina R. Oliveira,Karen M. Rodrigue,Johannes Kornhuber,Anders Wallin,Aleksandra Klimkowicz-Mrowiec,Ramesh Kandimalla,Julius Popp,Pauline Aalten,Dag Aarsland,Daniel Alcolea,Ina S. Almdahl,Inês Baldeiras,Mark A. van Buchem,Enrica Cavedo,Kewei Chen,Ann D. Cohen,Stefan Förster,Juan Fortea,Kristian Steen Frederiksen,Yvonne Freund-Levi,Kiran Dip Gill,Olymbia Gkatzima,Timo Grimmer,Harald Hampel,Harald Hampel,Sanna-Kaisa Herukka,Peter Johannsen,Koen Van Laere,Mony J. de Leon,Wolfgang Maier,Jan Marcusson,Olga Meulenbroek,Hanne M. Møllergård,John C. Morris,Barbara Mroczko,Arto Nordlund,Sudesh Prabhakar,Oliver Peters,Lorena Rami,Eloy Rodríguez-Rodríguez,Catherine M. Roe,Eckart Rüther,Isabel Santana,Johannes Schröder,Sang W. Seo,Hilkka Soininen,Luiza Spiru,Erik Stomrud,Hanne Struyfs,Charlotte E. Teunissen,Frans R.J. Verhey,Stephanie J.B. Vos,Linda J C van Waalwijk van Doorn,Gunhild Waldemar,Åsa K. Wallin,Jens Wiltfang,Rik Vandenberghe,David J. Brooks,Tormod Fladby,Christopher C. Rowe,Alexander Drzezga,Marcel M. Verbeek,Marie Sarazin,David A. Wolk,Adam S. Fleisher,Adam S. Fleisher,William E. Klunk,Duk L. Na,Pascual Sánchez-Juan,Dong Young Lee,Agneta Nordberg,Magda Tsolaki,Vincent Camus,Juha O. Rinne,Anne M. Fagan,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Gil D. Rabinovici,Oskar Hansson,Bart N.M. van Berckel,Wiesje M. van der Flier,Philip Scheltens,Pieter Jelle Visser,Pieter Jelle Visser,Rik Ossenkoppele,Rik Ossenkoppele +99 more
TL;DR: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease, but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology.
Journal ArticleDOI
Convergence between Lesion-Symptom Mapping and Functional Magnetic Resonance Imaging of Spatially Selective Attention in the Intact Brain
TL;DR: For example, this article found that patients with a right inferior parietal lesion were significantly more impaired during contralesional versus ipsilesional orienting when stimuli were bilateral and symmetrical than when stimuli occupied diagonally opposite quadrants or two quadrants within the same hemifield.
Journal ArticleDOI
Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients
Federica Perrone,Hung Phuoc Nguyen,Sara Van Mossevelde,Matthieu Moisse,Anne Sieben,Anne Sieben,Patrick Santens,Jan De Bleecker,Mathieu Vandenbulcke,Sebastiaan Engelborghs,Jonathan Baets,Patrick Cras,Rik Vandenberghe,Peter De Jonghe,Peter Paul De Deyn,Jean-Jacques Martin,Philip Van Damme,Christine Van Broeckhoven,Julie van der Zee,Dirk Nuytten,Katrien Smets,Jan Versijpt,Alex Michotte,Adrian Ivanoiu,Olivier Deryck,Bruno Bergmans,Jean Delbeck,Marc Bruyland,Christiana Willems,Eric Salmon +29 more
TL;DR: The present study confirms the role of CHCHD10 and TUBA4A in the FTD-ALS spectrum, although genetic variations in these 2 genes are extremely rare in the Belgian population and often associated with symptomatology of related neurodegenerative diseases including Parkinson's disease and Alzheimer's disease.
Journal ArticleDOI
APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation
Jerome Mertens,Kathrin Stüber,Patrick Wunderlich,Julia Ladewig,Jaideep Kesavan,Rik Vandenberghe,Mathieu Vandenbulcke,Philip Van Damme,Jochen Walter,Oliver Brüstle,Philipp Koch +10 more
TL;DR: This work reveals resistance of human neurons to NSAID-based γ-secretase modulation, highlighting the need to validate compound efficacy directly in the human cell type affected by the respective disease.
Journal ArticleDOI
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
Daniel Stamate,Daniel Stamate,Min Kim,Petroula Proitsi,Sarah Westwood,Alison L. Baird,Alejo J. Nevado-Holgado,Abdul Hye,Isabelle Bos,Isabelle Bos,Stephanie J.B. Vos,Rik Vandenberghe,Charlotte E. Teunissen,Mara ten Kate,Mara ten Kate,Philip Scheltens,Silvy Gabel,Silvy Gabel,Karen Meersmans,Olivier Blin,Jill C. Richardson,Ellen Elisa De Roeck,Ellen Elisa De Roeck,Sebastiaan Engelborghs,Sebastiaan Engelborghs,Kristel Sleegers,Régis Bordet,Lorena Ramit,Petronella Kettunen,Magda Tsolaki,Frans R.J. Verhey,Daniel Alcolea,Alberto Lleó,Gwendoline Peyratout,Mikel Tainta,Peter Johannsen,Yvonne Freund-Levi,Yvonne Freund-Levi,Lutz Frölich,Valerija Dobricic,Giovanni B. Frisoni,José Luis Molinuevo,José Luis Molinuevo,Anders Wallin,Julius Popp,Julius Popp,Pablo Martinez-Lage,Lars Bertram,Lars Bertram,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Johannes Streffer,Pieter Jelle Visser,Pieter Jelle Visser,Simon Lovestone,Simon Lovestone,Cristina Legido-Quigley,Cristina Legido-Quigley +58 more
TL;DR: This work sets out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers to capture the metabolic complexity in Alzheimer Disease.