R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density
Craig Curtis,Jose Gamez,Upinder Singh,Carl H. Sadowsky,Teresa Villena,Marwan N. Sabbagh,Thomas G. Beach,Ranjan Duara,Adam S. Fleisher,Adam S. Fleisher,Kirk A. Frey,Zuzana Walker,Zuzana Walker,Arvinder Hunjan,Clive Holmes,Yavir M. Escovar,Carla X. Vera,Marc Agronin,Joel Ross,Andrea Bozoki,Mary Akinola,Jiong Shi,Rik Vandenberghe,Milos D. Ikonomovic,Paul Sherwin,Igor D. Grachev,Igor D. Grachev,G. Farrar,Adrian Smith,Christopher Buckley,Richard McLain,Stephen Salloway,Stephen Salloway +32 more
TL;DR: This study showed that flutemetamol injection labeled with radioactive fluorine 18 was safe and had high sensitivity and specificity in an end-of-life population and may increase diagnostic accuracy in cognitively impaired patients.
Journal ArticleDOI
Functional specificity of superior parietal mediation of spatial shifting
TL;DR: The response to spatial shifts and the correlation with the distance between the original and the new location points to a specific role of the superior parietal gyrus in shifting the locus of spatial attention.
Journal ArticleDOI
Genetic contribution of FUS to frontotemporal lobar degeneration
T Van Langenhove,J. van der Zee,K. Sleegers,S. Engelborghs,Rik Vandenberghe,I. Gijselinck,M Van den Broeck,Maria Mattheijssens,K. Peeters,P.P. De Deyn,Marc Cruts,C. Van Broeckhoven +11 more
TL;DR: In a first analysis of FUS in patients with frontotemporal lobar degeneration (FTLD), a novel FUS missense mutation, M254V, is identified in 1 patient with pure FTLD, suggesting that G-insertions/deletions within this G-rich region may be tolerated.
Journal ArticleDOI
The kinetic occipital region in human visual cortex.
Patrick Dupont,B De Bruyn,Rik Vandenberghe,Anne-Marie Rosier,Johan Michiels,Guy Marchal,Luc Mortelmans,Guy Orban +7 more
TL;DR: It is shown that the kinetic occipital (KO) region, located laterally in Occipital cortex approximately 20 mm behind human MT/V5, can be strongly and bilaterally activated under passive viewing conditions.
Journal ArticleDOI
Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials.
Rik Vandenberghe,Juha O. Rinne,Mercè Boada,Sadao Katayama,Philip Scheltens,Bruno Vellas,Michael Tuchman,Achim Gass,Jochen B. Fiebach,Derek L. G. Hill,Kasia Lobello,David Li,Tom McRae,Prisca Lucas,Iona Evans,Kevin Booth,Gerald Luscan,Bradley T. Wyman,Lisa Hua,Lingfeng Yang,H. Robert Brashear,Ronald Black +21 more
TL;DR: These phase 3 global trials confirmed lack of efficacy of bapineuzumab at tested doses on clinical endpoints in patients with mild to moderate Alzheimer’s disease.