R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Direct prospective comparison of 18F-FDG PET and arterial spin labelling MR using simultaneous PET/MR in patients referred for diagnosis of dementia
Jenny Ceccarini,Sophie Bourgeois,Donatienne Van Weehaeghe,Karolien Goffin,Rik Vandenberghe,Mathieu Vandenbulcke,Stefan Sunaert,Koen Van Laere +7 more
TL;DR: In a direct head-to-head comparison on a simultaneous GE Signa PET/MR, 18F-FDG PET performed better compared with ASL in terms of sensitivity and reader confidence, as well as volume and intensity of abnormalities, but ASL may still serve as complement to neuroreceptor or protein deposition PET studies when a single simultaneous investigation is warranted.
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Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia
Golia Shafiei,Vincent Bazinet,Mahsa Dadar,Ana L. Manera,D. Louis Collins,Alain Dagher,S. Borroni,Raquel Sánchez-Valle,Fermin Moreno,Robert Laforce,Caroline Graff,Matthis Synofzik,Daniela Galimberti,James B. Rowe,Mario Masellis,Maria Carmela Tartaglia,Elizabeth Finger,Rik Vandenberghe,Alexandre de Mendonça,Fabrizio Tagliavini,Isabel Santana,Christopher C Butler,Alexander Gerhard,Adrian Danek,Johannes Levin,Markus Otto,Sandro Sorbi,Lize C. Jiskoot,Harro Seelaar,John C. van Swieten,Jonathan D. Rohrer,Bratislav Misic,Simon Ducharme +32 more
TL;DR: It is demonstrated that atrophy patterns in sporadic and genetic bvFTD are jointly shaped by global connectome architecture and local transcriptomic vulnerability, providing an explanation as to how heterogenous pathological entities can lead to the same clinical syndrome.
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Symptomatic internal carotid artery dissecting pseudoaneurysm: endovascular treatment by stent-graft
TL;DR: A case in which pseudoaneurysm volume enlarged progressively and new clinical symptoms developed 9 months following disease onset is reported, and placement of a coronary stent-graft resulted in immediate complete resolution of clinical symptoms and radiologic restoration of normal flow.
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Extended FTLD pedigree segregating a Belgian GRN -null mutation: neuropathological heterogeneity in one family
Anne Sieben,Anne Sieben,Sara Van Mossevelde,Eline Wauters,Sebastiaan Engelborghs,Julie van der Zee,Tim Van Langenhove,Tim Van Langenhove,Patrick Santens,Marleen Praet,Paul Boon,Marijke Miatton,Sofie Van Hoecke,Mathieu Vandenbulcke,Rik Vandenberghe,Patrick Cras,Marc Cruts,Peter Paul De Deyn,Peter Paul De Deyn,Christine Van Broeckhoven,Jean-Jacques Martin +20 more
TL;DR: Comparisons with published clinical and neuropathological characteristics of other GRN mutations as well as other frontotemporal lobar degeneration (FTLD) syndromes show not only that the IVS1’+ 5G’> C mutation has an exclusive association with FTLD-TDP type A proteinopathy but also that other proteinopathies can occur and should be looked for.
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Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants.
Jolien Schaeverbeke,Charlotte Evenepoel,Lieven Declercq,Silvy Gabel,Karen Meersmans,Rose Bruffaerts,Kate Adamczuk,Eva Dries,Karen Van Bouwel,Anne Sieben,Yolande A.L. Pijnenburg,Ronald Peeters,Guy Bormans,Koen Van Laere,Michel Koole,Patrick Dupont,Rik Vandenberghe +16 more
TL;DR: High resolution PET tracer imaging shows a topography closely matching the anatomical distribution of predicted underlying pathology characteristic of NFV and SV PPA, and correlates with the severity of clinical impairment.