R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes
Sandra O. Tomé,Rik Vandenberghe,Simona Ospitalieri,Evelien Van Schoor,Evelien Van Schoor,Thomas Tousseyn,Markus Otto,Christine A. F. von Arnim,Christine A. F. von Arnim,Dietmar Rudolf Thal,Dietmar Rudolf Thal +10 more
TL;DR: Evidence is provided that TDP-43 aggregates occurring in AD cases vary in their composition, suggesting the distinction of different molecular patterns of T DP-43 pathology ranging from AD T DP’+ CTF and AD TDP +- FL with possible impact on their clinical picture, i.e. a higher chance for FTD-like symptoms in ADTDP+FL cases.
Journal ArticleDOI
Classification of the primary progressive aphasias: principles and review of progress since 2011.
TL;DR: Given the limited predictive value of the clinical phenotype for the underlying neuropathology, biomarkers of the underlying pathology are likely of clinical utility in PPA.
Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study
Rik Vandenberghe,Marie Emmanuelle Riviere,Angelika Caputo,Judit Sovago,R. Paul Maguire,Martin R. Farlow,Giovanni Marotta,Raquel Sánchez-Valle,Philip Scheltens,J. Michael Ryan,Ana Graf +10 more
TL;DR: A randomized, double-blind, placebo-controlled, 90-week study assessed safety, tolerability, and immunogenicity of CAD106 with/without adjuvant in patients with mild Alzheimer's disease.
Journal ArticleDOI
Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.
Daniel Pirici,Rik Vandenberghe,Rosa Rademakers,Bart Dermaut,Marc Cruts,Krist'l Vennekens,Ivy Cuijt,U. Lübke,Chantal Ceuterick,Jean Jacques Martin,Christine Van Broeckhoven,Samir Kumar-Singh +11 more
TL;DR: A four-generation Belgian FTLD family in which 8 patients had dominantly inherited FTLD is identified, and characterization of such familial FTLD-U patients would be helpful in identifying a common denominator in the pathogenesis of familial and the more prevalent sporadic FT LD-U.
Journal ArticleDOI
Autoimmune-mediated encephalitis.
Philippe Demaerel,Wim Van Dessel,Wim Van Paesschen,Rik Vandenberghe,Koen Van Laere,Jennifer Linn +5 more
TL;DR: The role of neuroimaging in autoimmune-mediated encephalitis has changed in the last decade partly due to improvements in sequence optimisation and higher field strength and part due to the discovery of an increasing number of antibodies to neuronal cell and cell membrane antigens.