R
Rik Vandenberghe
Researcher at Allen Institute for Brain Science
Publications - 430
Citations - 26622
Rik Vandenberghe is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 69, co-authored 355 publications receiving 21180 citations. Previous affiliations of Rik Vandenberghe include Northwestern University & Katholieke Universiteit Leuven.
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Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia
Kamen A. Tsvetanov,Stefano Gazzina,P. Simon Jones,John C. van Swieten,Barbara Borroni,Raquel Sánchez-Valle,Fermin Moreno,Robert Laforce,Caroline Graff,Matthis Synofzik,Daniela Galimberti,Mario Masellis,Maria Carmela Tartaglia,Elizabeth Finger,Rik Vandenberghe,Alexandre de Mendonça,Fabrizio Tagliavini,Isabel Santana,Simon Ducharme,Christopher C Butler,Alexander Gerhard,Adrian Danek,Johannes Levin,Markus Otto,Giovanni B. Frisoni,Roberta Ghidoni,Sandro Sorbi,Jonathan D. Rohrer,James B. Rowe +28 more
TL;DR: The findings suggest that maintenance of functional network connectivity enables carriers to maintain cognitive performance, and coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease.
Journal ArticleDOI
Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study.
Babette L.R. Reijs,Inez H.G.B. Ramakers,Sebastian Köhler,Charlotte E. Teunissen,Marleen J.A. Koel-Simmelink,Pradeep J. Nathan,Pradeep J. Nathan,Magda Tsolaki,Lars-Olof Wahlund,Gunhild Waldemar,Lucrezia Hausner,Rik Vandenberghe,Peter Johannsen,Andrew D. Blackwell,Hugo Vanderstichele,Frans R.J. Verhey,Pieter Jelle Visser,Pieter Jelle Visser +17 more
TL;DR: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology, and tests for episodicverbal memory and semantic memory aremost useful for tracking memory decline.
Journal ArticleDOI
Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults
Katarzyna Adamczuk,An-Sofie De Weer,Natalie Nelissen,Natalie Nelissen,Patrick Dupont,Stefan Sunaert,Karolien Bettens,Kristel Sleegers,Christine Van Broeckhoven,Koen Van Laere,Rik Vandenberghe +10 more
TL;DR: Higher activity in one region, the posterior left middle temporal gyrus, correlated positively with increased amyloid load, and offline naming reaction times correlated negatively with SUVR(comp), confirming findings of word finding symptoms in cognitively intact older adults.
Journal ArticleDOI
Parametric imaging and quantitative analysis of the PET amyloid ligand [(18)F]flutemetamol
TL;DR: Parametric imaging allows for quantification without introducing bias due to selection of anatomical regions, and thus enables objective statistical voxel-based comparisons of tracer binding, thus supporting its use as a simplified method for quantitative assessment oftracer uptake.
Journal ArticleDOI
Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases.
Lieselot Dedeene,Evelien Van Schoor,Rik Vandenberghe,Rik Vandenberghe,Philip Van Damme,Koen Poesen,Dietmar Rudolf Thal +6 more
TL;DR: The neuropathological findings show that pinealocytes and, to a lesser extent, SCN-related neurons are affected by DPR pathology, which may reflect an involvement of these cells in sleep/wake disturbances observed in ALS and/or FTLD-TDP patients.