R
Roderic Guigó
Researcher at Pompeu Fabra University
Publications - 475
Citations - 121421
Roderic Guigó is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Computer science & Gene. The author has an hindex of 108, co-authored 304 publications receiving 106914 citations. Previous affiliations of Roderic Guigó include University of Barcelona & Harvard University.
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Journal ArticleDOI
Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
Natalia Vilor-Tejedor,Iacopo Ciampa,Grégory Operto,Carles Falcon,Marc Suárez-Calvet,Marta Crous-Bou,Mahnaz Shekari,Eider M. Arenaza-Urquijo,Marta Milà-Alomà,Oriol Grau-Rivera,Carolina Minguillon,Gwendlyn Kollmorgen,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Roderic Guigó,José Luis Molinuevo,Juan Domingo Gispert,Annabella Beteta,Anna Brugulat,Raffaele Cacciaglia,Alba Cañas,Carme Deulofeu,Irene Cumplido,Ruth Dominguez,Maria Emilio,Karine Fauria,Sherezade Fuentes,Laura Hernandez,Gema Huesa,Jordi Huguet,Paula Marne,Tania Menchon,Albina Polo,Sandra Pradas,Blanca Rodriguez-fernandez,Aleix Sala-Vila,Gonzalo Sánchez-Benavides,Gemma Salvadó,Anna Soteras,Marc Vilanova +40 more
TL;DR: In this article, the authors presented the results of the TriBEKa imaging platform project with the support of the Spanish Ministry of Science, Innovation and Universities to the EMBL partnership, Centro de Excelencia Severo Ochoa, and the CERCA Programme/Generalitat de Catalunya.
Posted ContentDOI
Conserved long-range RNA structures associated with pre-mRNA processing of human protein-coding genes
Svetlana Kalmykova,Marina A. Kalinina,Stepan Denisov,Aleksei Mironov,Dmitry A. Skvortsov,Roderic Guigó,Dmitri D. Pervouchine +6 more
TL;DR: This work presents the most complete to-date catalog of conserved long-range RNA structures in the human transcriptome, which consists of 916,360 pairs of Conserved complementary regions (PCCRs) and suggests that RNA folding coupled with splicing could mediate co-transcriptional suppression of premature cleavage and polyadenylation events.
Journal ArticleDOI
BioMoby web services to support clustering of co-regulated genes based on similarity of promoter configurations
Arnaud Kerhornou,Roderic Guigó +1 more
TL;DR: A computational protocol to analyze the promoter regions of a given set of co-expressed genes, and its implementation through the use of Web services technologies that are compliant with BioMoby specifications is presented.
Journal ArticleDOI
Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing
TL;DR: The results suggest that antagonism between SRSF1 and S RSF2/HMGA1, and differential recognition of their regulatory motifs depending on the identity of the rs3736234 polymorphism, influence OLR1 exon 5 inclusion and the efficiency of Ox-LDL uptake, with potential implications for atherosclerosis and coronary disease.
Journal ArticleDOI
Unravelling the hidden DNA structural/physical code provides novel insights on promoter location
Elisa Durán,Sarah Djebali,Santi González,Oscar Flores,Josep M. Mercader,Roderic Guigó,David Torrents,Montserrat Soler-López,Modesto Orozco +8 more
TL;DR: The present study strongly supports the hypothesis of an ancient regulatory mechanism encoded by the intrinsic physical properties of the DNA that may contribute to the complexity of transcription regulation in the human genome.