R
Roderic Guigó
Researcher at Pompeu Fabra University
Publications - 475
Citations - 121421
Roderic Guigó is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Computer science & Gene. The author has an hindex of 108, co-authored 304 publications receiving 106914 citations. Previous affiliations of Roderic Guigó include University of Barcelona & Harvard University.
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Journal ArticleDOI
Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes
Marco Mariotti,Perry G. Ridge,Yan Zhang,Yan Zhang,Alexei V. Lobanov,Thomas H. Pringle,Roderic Guigó,Dolph L. Hatfield,Vadim N. Gladyshev +8 more
TL;DR: This analysis represents the first comprehensive survey of the vertebrate and mammal selenoproteomes, and depicts their evolution along lineages and provides a wealth of information on these selenobroteins and their forms.
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Pseudogenes in the ENCODE regions: Consensus annotation, analysis of transcription, and evolution
Deyou Zheng,Adam Frankish,Robert Baertsch,Philipp Kapranov,Alexandre Reymond,Alexandre Reymond,Siew Woh Choo,Yontao Lu,Stylianos E. Antonarakis,Michael Snyder,Yijun Ruan,Chia-Lin Wei,Thomas R. Gingeras,Roderic Guigó,Jennifer Harrow,Mark Gerstein +15 more
TL;DR: This work extensively examined the transcriptional activity of the ENCODE pseudogenes and performed systematic series of pseudogene-specific RACE analyses, demonstrating that at least a fifth of the 201 pseudogene are transcribed in one or more cell lines or tissues.
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CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis
Samir Ounzain,Rudi Micheletti,Carme Arnan,Isabelle Plaisance,Dario Cecchi,Blanche Schroen,Ferran Reverter,Michael Alexanian,Christine Gonzales,Shi-Yan Ng,Shi-Yan Ng,Giovanni Bussotti,Iole Pezzuto,Cedric Notredame,Stephane Heymans,Roderic Guigó,Rory Johnson,Thierry Pedrazzini +17 more
TL;DR: It is demonstrated that CARMEN expression was activated during pathological remodeling in the mouse and human hearts, and was necessary for maintaining cardiac identity in differentiated cardiomyocytes, and is a crucial regulator of cardiac cell differentiation and homeostasis.
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An Assessment of Gene Prediction Accuracy in Large DNA Sequences
TL;DR: Though gene prediction will improve with every new protein that is discovered and through improvements in the current set of tools, there is a long way to go before the authors can decipher the precise exonic structure of every gene in the human genome using purely computational methodology.
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Tandem chimerism as a means to increase protein complexity in the human genome
Genís Parra,Alexandre Reymond,Noura Dabbouseh,Emmanouil T. Dermitzakis,Robert Castelo,Timothy M. Thomson,Stylianos E. Antonarakis,Roderic Guigó +7 more
TL;DR: Strong evidence is provided that at least 4%-5% of the tandem gene pairs in the human genome can be eventually transcribed into a single RNA sequence encoding a putative chimeric protein, and that this phenomenon is a common mechanism with the potential of generating hundreds of additional proteins in thehuman genome.