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Roderic Guigó

Researcher at Pompeu Fabra University

Publications -  475
Citations -  121421

Roderic Guigó is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Computer science & Gene. The author has an hindex of 108, co-authored 304 publications receiving 106914 citations. Previous affiliations of Roderic Guigó include University of Barcelona & Harvard University.

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Erratum: Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (14936-14941) DOI 10.1073/pnas.1506226112)

Rafael D. Mesquita, +118 more
Journal ArticleDOI

The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry

TL;DR: The functional impact of the structural and dynamic asymmetry in the biological activities of hybrids is dramatic and can be used to improve the efficiency of antisense-type strategies on the basis of the degradation of hybrids by RNase H or gene editing using CRISPR-Cas9 technology.
Posted ContentDOI

Dynamics of gene expression and chromatin marking during cell state transition

TL;DR: Monitoring the transcriptomic and epigenomic status of cells at twelve time-points during the transdifferentiation of human pre-B cells into macrophages has found that, over time, genes are characterized by a limited number of chromatin states (combinations of histone modifications), and that, consistently, chromatin changes over genes tend to occur in a coordinated manner.
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Day-night and seasonal variation of human gene expression across tissues

TL;DR: In this paper , the authors used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues and provided the first combined atlas of how transcriptomes from human tissues adapt to major cycling environmental conditions.