R
Roderic Guigó
Researcher at Pompeu Fabra University
Publications - 475
Citations - 121421
Roderic Guigó is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Computer science & Gene. The author has an hindex of 108, co-authored 304 publications receiving 106914 citations. Previous affiliations of Roderic Guigó include University of Barcelona & Harvard University.
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Journal ArticleDOI
Computational identification of the selenocysteine tRNA (tRNASec) in genomes.
TL;DR: Secmarker greatly improves the accuracy of previously existing methods constituting a valuable tool to identify tRNASec genes, and to efficiently determine whether a genome contains selenoproteins, and is used to analyze a large set of fully sequenced genomes.
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Efficient targeted transcript discovery via array-based normalization of RACE libraries.
Sarah Djebali,Philipp Kapranov,Sylvain Foissac,Julien Lagarde,Alexandre Reymond,Catherine Ucla,Carine Wyss,Jorg Drenkow,Erica Dumais,Ryan R. Murray,Chenwei Lin,David Szeto,Miquel Calvo,Adam Frankish,Jennifer Harrow,Periklis Makrythanasis,Marc Vidal,Kourosh Salehi-Ashtiani,Stylianos E. Antonarakis,Thomas R. Gingeras,Roderic Guigó +20 more
TL;DR: This work hybridized the products of the RACE reaction onto tiling arrays and used the detected exons to delineate a series of reverse-transcriptase (RT)-PCRs, through which the original RACE transcript population was segregated into simpler transcript populations.
Journal ArticleDOI
Improving data and knowledge management to better integrate health care and research
Montserrat Cases,Laura I. Furlong,Joan Albanell,Russ B. Altman,Riccardo Bellazzi,Scott Boyer,Angela Brand,Anthony J. Brookes,Søren Brunak,T. W. Clark,Joaquim Gea,Peter Ghazal,Norbert Graf,Roderic Guigó,Teri E. Klein,Nuria Lopez-Bigas,Victor Maojo,Barend Mons,Mark A. Musen,José Luís Oliveira,Alex Rowe,Patrick Ruch,Amnon Shabo,Edward H. Shortliffe,Alfonso Valencia,J. van der Lei,Michael Mayer,Ferran Sanz +27 more
TL;DR: This review is based on the debates held in Barcelona from 3 July 2012 to 4 July 2012 with the active participation of all authors.
Journal ArticleDOI
Dynamic changes in intron retention are tightly associated with regulation of splicing factors and proliferative activity during B-cell development
Sebastian Ullrich,Roderic Guigó +1 more
TL;DR: This work provides new insights into the role of IR during hematopoiesis, and on the main factors involved in regulating IR, by correlating the expression of non-core splicing factors with global IR levels, and analyzing RNA binding protein knockdown and eCLIP data.
Posted ContentDOI
Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome
TL;DR: It is found that sQTLs often target the global splicing pattern of genes, rather than individual splicing events, and tend to be preferentially located in introns that are post-transcriptionally spliced, which would act as hotspots for splicing regulation.