Ruchao Peng

TL;DR: The isolation of 13 specific human monoclonal antibodies from a patient infected with Zika virus suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.

TL;DR: The near-atomic resolution structure of the SARS-CoV-2 polymerase complex, consisting of nsp12 catalytic subunit and nsp7-nsp8 cofactors, is described, providing important insights into RNA synthesis by coronavirus polymerase and indicate a well adaptation of Sars-Cov-2 towards humans with relatively lower body temperatures than the natural bat hosts.

TL;DR: The cryogenic electron microscopy (cryo-EM) structure of the icosahedral capsid of ASFV at 4.6-Å is described, providing a comprehensive molecular model of the AsFV capsid architecture that will contribute to the future development of countermeasures, including vaccines.

TL;DR: In this paper, the authors discuss the recent advances in understanding the molecular events during SARS-CoV-2 entry which will contribute to developing vaccines and therapeutics, and discuss some auxiliary receptors and cofactors are also involved that expand the host/tissue tropism.

TL;DR: Cryo-electron microscopy structures revealed that human neonatal Fc receptor (FcRn) is the uncoating receptor for major EV-B, providing a structural basis for understanding the mechanisms of enterovirus entry.