R
Ruihan Zhang
Researcher at Yunnan University
Publications - 68
Citations - 1094
Ruihan Zhang is an academic researcher from Yunnan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 12, co-authored 42 publications receiving 677 citations. Previous affiliations of Ruihan Zhang include German Cancer Research Center & Chinese Academy of Sciences.
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Journal ArticleDOI
Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
Baoen Chen,Fei Ye,Lu Yu,Guifang Jia,Xiaotian Huang,X.-B. Zhang,Shuying Peng,Kai Chen,Meining Wang,Shouze Gong,Ruihan Zhang,Jinya Yin,Haiyan Li,Yiming Yang,Hong Liu,Jiwen Zhang,Hai-Yan Zhang,Ao Zhang,Hualiang Jiang,Cheng Luo,Cai-Guang Yang,Cai-Guang Yang +21 more
TL;DR: The first identification of several small-molecule inhibitors of human FTO demethylase is reported, including the most potent compound, the natural product rhein, which is neither a structural mimic of 2-oxoglutarate nor a chelator of metal ion.
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Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase.
Jie Zhang,Hongchuan Liu,Kongkai Zhu,Shouzhe Gong,Shaynoor Dramsi,Ya-Ting Wang,Jiafei Li,Feifei Chen,Ruihan Zhang,Lu Zhou,Lefu Lan,Hualiang Jiang,Olaf Schneewind,Cheng Luo,Cai-Guang Yang +14 more
TL;DR: Virtual screening and optimization of inhibitor structure is used to identify 3,6-disubstituted triazolothiadiazole compounds as inhibitors of sortase, an enzyme that incorporates surface proteins into the staphylococcal envelope that may prevent hospital-acquired S. aureus infection in high-risk patients without the side effects of antibiotics.
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Histone Acetylation Regulates Chromatin Accessibility: Role of H4K16 in Inter-nucleosome Interaction
TL;DR: This study suggests that H4K16Ac directly reduces the inter-nucleosome interaction mediated by the H4 tail, which might further encourage the binding of nonhistone proteins on the acidic patch.
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The Role of Histone Tails in the Nucleosome: A Computational Study
TL;DR: Results from both implicit and explicit solvent models show that large portions of the histone tails are not bound to DNA, supporting the complex role of these tails in gene transcription and expression and making them possible candidates for binding sites of transcription factors, enzymes, and other proteins.
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Phytochemistry and pharmacology of the genus Leonurus: The herb to benefit the mothers and more
TL;DR: Anti-inflammation is the major bioactivity discovered so far for the labdane diterpenoids from the genus Leonurus, whose further therapeutic potential still remains for exploration.