S
Sang Yong Kim
Researcher at Cold Spring Harbor Laboratory
Publications - 14
Citations - 3312
Sang Yong Kim is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Gene & Embryonic stem cell. The author has an hindex of 9, co-authored 11 publications receiving 3115 citations. Previous affiliations of Sang Yong Kim include Watson School of Biological Sciences.
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Journal ArticleDOI
Dicer is essential for mouse development.
Emily Bernstein,Sang Yong Kim,Michelle A. Carmell,Michelle A. Carmell,Elizabeth P. Murchison,Heather L. Alcorn,Mamie Z. Li,Alea A. Mills,Stephen J. Elledge,Kathryn V. Anderson,Gregory J. Hannon +10 more
TL;DR: A role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development is suggested.
Journal ArticleDOI
miR-34 miRNAs provide a barrier for somatic cell reprogramming.
Yong Jin Choi,Chao Po Lin,Jaclyn J. Ho,Xingyue He,Nobuhiro Okada,Pengcheng Bu,Yingchao Zhong,Sang Yong Kim,Margaux J Bennett,Caifu Chen,Arzu Öztürk,Geoffrey G. Hicks,Greg J. Hannon,Lin He +13 more
TL;DR: These findings identified miR-34 miRNAs as p53 targets that play an essential role in restraining somatic reprogramming.
Journal ArticleDOI
A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Prem K. Premsrirut,Prem K. Premsrirut,Lukas E. Dow,Sang Yong Kim,Matthew Camiolo,Matthew Camiolo,Colin D. Malone,Colin D. Malone,Cornelius Miething,Claudio Scuoppo,Claudio Scuoppo,Johannes Zuber,Ross A. Dickins,Ross A. Dickins,Scott C. Kogan,Kenneth R. Shroyer,Raffaella Sordella,Gregory J. Hannon,Gregory J. Hannon,Scott W. Lowe,Scott W. Lowe +20 more
TL;DR: This system provides a cost-effective and scalable platform for the production of RNAi transgenic mice targeting any mammalian gene and validates APC/Wnt and p19(ARF) as potential therapeutic targets in T cell acute lymphoblastic leukemia/lymphoma and lung adenocarcinoma, respectively.
Journal ArticleDOI
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
Matthias Stadtfeld,Effie Apostolou,Francesco Ferrari,Jiho Choi,Ryan M. Walsh,Taiping Chen,Steen S.K. Ooi,Steen S.K. Ooi,Sang Yong Kim,Timothy H. Bestor,Toshi Shioda,Peter J. Park,Konrad Hochedlinger +12 more
TL;DR: It is shown that reprogramming in the presence of ascorbic acid attenuates hypermethylation of Dlk1-Dio3 by enabling a chromatin configuration that interferes with binding of the de novo DNA methyltransferase Dnmt3a.
Journal ArticleDOI
Tissue-specific and reversible RNA interference in transgenic mice
Ross A. Dickins,Katherine McJunkin,Katherine McJunkin,Eva Hernando,Prem K. Premsrirut,Valery Krizhanovsky,Darren J. Burgess,Darren J. Burgess,Sang Yong Kim,Carlos Cordon-Cardo,Lars Zender,Gregory J. Hannon,Gregory J. Hannon,Gregory J. Hannon,Scott W. Lowe,Scott W. Lowe,Scott W. Lowe +16 more
TL;DR: A simple transgenic system to reversibly control endogenous gene expression using RNA interference (RNAi) in mice by adapting the tetracycline (tet)-responsive system previously used for gene overexpression, with potential broad application in basic biology and drug target validation.