Sara R. Selitsky

TL;DR: The NFE2L2‐KEAP1 and MLL pathways are recurrently mutated in multiple cohorts of HCC, with significantly affected gene families include the nucleotide‐binding domain and leucine‐rich repeat‐containing family, calcium channel subunits, and histone methyltransferases.

TL;DR: HervQuant provides insights into the role of hERVs within the tumor immune microenvironment, as well as evidence that hERV expression could serve as a biomarker for patient prognosis and response to immunotherapy.

TL;DR: Examples of TSAs alternative to the traditional single-nucleotide variant neoantigens are provided and details about the novel computational tools used to identify them are provided, with the view to broaden the number of targetable antigens that can be used for cancer vaccine development.

TL;DR: A molecular subtype of bladder cancer with distinct molecular features and an immunologic profile that would, in theory, be primed for immunotherapeutic response is found.

TL;DR: Given the unique biology of BC in men, promising new therapeutic targets are currently under investigation, including the use of poly-ADP-ribose polymerase inhibitors or AR-targeted agents either as monotherapy or in combination with other agents.