S
Sarah Curran
Researcher at King's College London
Publications - 78
Citations - 7948
Sarah Curran is an academic researcher from King's College London. The author has contributed to research in topics: Autism & Attention deficit hyperactivity disorder. The author has an hindex of 36, co-authored 77 publications receiving 7179 citations. Previous affiliations of Sarah Curran include Sussex Partnership NHS Foundation Trust & Brighton and Sussex Medical School.
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Journal ArticleDOI
Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.
Richard Paylor,Beate Glaser,Annalisa Mupo,Paris Ataliotis,Corinne M. Spencer,Angela Sobotka,Chelsey Sparks,Chul-Hee Choi,John S. Oghalai,Sarah Curran,Kieran C. Murphy,Stephen Monks,Nigel Williams,Michael Conlon O'Donovan,Michael John Owen,Peter J. Scambler,Elizabeth A. Lindsay +16 more
TL;DR: It is shown that PPI deficits in Df1/+ mice are caused by haploinsufficiency of two genes, Tbx1 and Gnb1l, which are strong candidates for psychiatric disease in 22q11DS patients and candidate susceptibility genes in the wider population.
Journal ArticleDOI
Altered cerebellar feedback projections in Asperger syndrome
Marco Catani,Derek K. Jones,Eileen Daly,Nitzia Embiricos,Quinton Deeley,Luca Pugliese,Sarah Curran,Dene Robertson,Declan G. Murphy +8 more
TL;DR: A vulnerability of specific cerebellar neural pathways in people with Asperger syndrome is suggested, which may prevent the cerebral cortex from receiving those Cerebellar feedback inputs necessary for a successful adaptive social behaviour.
Journal ArticleDOI
Rare Deletions at the Neurexin 3 Locus in Autism Spectrum Disorder
Andrea K. Vaags,Anath C. Lionel,Anath C. Lionel,Daisuke Sato,McKinsey L. Goodenberger,Quinn Stein,Sarah Curran,Caroline Mackie Ogilvie,Joo Wook Ahn,Irene Drmic,Lili Senman,Christina Chrysler,Ann Thompson,Carolyn Russell,Aparna Prasad,Susan Walker,Dalila Pinto,Christian R. Marshall,Dimitri J. Stavropoulos,Lonnie Zwaigenbaum,Bridget A. Fernandez,Eric Fombonne,Patrick Bolton,David A. Collier,Jennelle C. Hodge,Wendy Roberts,Peter Szatmari,Stephen W. Scherer,Stephen W. Scherer +28 more
TL;DR: This report presents clinical characterization of four index cases who have been diagnosed with ASD and who possess rare inherited or de novo microdeletions at 14q24.3-31.1, a region that overlaps exons of the alpha and/or beta isoforms of NRXN3.
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Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample.
Ziarih Hawi,M. Dring,Aiveen Kirley,D Foley,Lindsey Kent,Nicholas John Craddock,P. Asherson,Sarah Curran,A Gould,S Richards,Daniel Lawson,H. Pay,D. Turic,Kate Langley,Michael John Owen,Michael Conlon O'Donovan,Anita Thapar,Michael Fitzgerald,M. Gill +18 more
TL;DR: Preliminary data suggest an important role for the serotonin system in the development of ADHD, and suggests that some of the genetic predisposition to ADHD might be due to DNA variation at serotonin system genes.
Journal ArticleDOI
Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study.
Declan G. Murphy,Eileen Daly,Nicole Schmitz,Fiona Toal,Keiran Murphy,Sarah Curran,Kjell Erlandsson,Jos Eersels,Robert Kerwin,Peter J. Ell,Michael J. Travis +10 more
TL;DR: The authors' findings suggest that adults with Asperger's syndrome have abnormalities in cortical 5-HT2A receptor density and that this deficit may underlie some clinical symptoms.