S
Sarah Curran
Researcher at King's College London
Publications - 78
Citations - 7948
Sarah Curran is an academic researcher from King's College London. The author has contributed to research in topics: Autism & Attention deficit hyperactivity disorder. The author has an hindex of 36, co-authored 77 publications receiving 7179 citations. Previous affiliations of Sarah Curran include Sussex Partnership NHS Foundation Trust & Brighton and Sussex Medical School.
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Journal ArticleDOI
Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD.
TL;DR: Overall, there is little evidence to support a role for DRD5 in ADHD, and there is significant association for an allele of D4S615, a dinucleotide repeat located 131 kb 3′ ofDRD5 that has been previously associated with schizophrenia.
Posted ContentDOI
A Genetics-First Approach to Dissecting the Heterogeneity of Autism: Phenotypic Comparison of Autism Risk Copy Number Variants
Samuel J.R.A. Chawner,Joanne L. Doherty,Richard Anney,Kevin M. Antshel,Carrie E. Bearden,Raphael Bernier,Wendy K. Chung,Caitlin C. Clements,Caitlin C. Clements,Sarah Curran,Goran Cuturilo,Ania M Fiksinski,Louise Gallagher,Robin P. Goin-Kochel,Leila Kushan,Raquel E. Gur,Raquel E. Gur,Ellen Hanson,Sébastien Jacquemont,Sébastien Jacquemont,Wendy R. Kates,A. Maillard,A. Maillard,Donna M. McDonald-McGinn,Donna M. McDonald-McGinn,Marina Mihaljevic,Judith Miller,Hayley Moss,Milica Pejovic-Milovancevic,Robert T. Schultz,Robert T. Schultz,LeeAnne Green-Snyder,Jacob A. S. Vorstman,Tara L. Wenger,Tara L. Wenger,Jeremy Hall,Michael John Owen,Marianne Bernadette van den Bree +37 more
TL;DR: Using clinical cut-offs, it is found that 54% of individuals with one of the 4 CNVs who did not meet full autism diagnostic criteria nonetheless had elevated levels of autistic traits, and a range of profile differences were identified.
Journal ArticleDOI
Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis.
Simone de Jong,Stephen Newhouse,Hamel Patel,Sang-hyuck Lee,David Dempster,Charles Curtis,Jose L. Paya-Cano,Declan G. Murphy,C. Ellie Wilson,Jamie Horder,M. Andreina Mendez,Philip Asherson,Margarita Rivera,Helen Costello,Stefanos Maltezos,Susannah Whitwell,Mark Pitts,Charlotte Tye,Karen L. Ashwood,Patrick Bolton,Sarah Curran,Peter McGuffin,Richard Dobson,Gerome Breen +23 more
TL;DR: W Weighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene Co-expression modules correlating inversely with MDD and adult ADHD disease status.
Journal ArticleDOI
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
Finian M. O'Brien,Finian M. O'Brien,Finian M. O'Brien,Lisa Page,Ruth L. O'Gorman,Patrick Bolton,Ajay Sharma,Gillian Baird,Eileen Daly,Brian Hallahan,Brian Hallahan,Ronan M. Conroy,Catherine Foy,Sarah Curran,Dene Robertson,Kieran C. Murphy,Kieran C. Murphy,Declan G. Murphy +17 more
TL;DR: It is suggested that people with Asperger syndrome have significant differences in neuronal and lipid membrane integrity and maturation of the AHC.
Journal ArticleDOI
No association between CHRNA7 microsatellite markers and attention‐deficit hyperactivity disorder
Lindsey Kent,Elaine K. Green,Jane Holmes,Anita Thapar,Michael Gill,Ziarah Hawi,Michael Fitzgerald,Philip Asherson,Sarah Curran,John Mills,A Payton,Nicholas John Craddock +11 more
TL;DR: Three known microsatellite markers near the nicotinic acetylcholine alpha 7 receptor gene, CHRNA7, were studied in 206 ADHD parent-proband trios of children aged 5-16 with ADHD according to DSM-IV criteria and demonstrated no evidence that variation at the micros satellite markers influences susceptibility to ADHD.