S
Sarah Curran
Researcher at King's College London
Publications - 78
Citations - 7948
Sarah Curran is an academic researcher from King's College London. The author has contributed to research in topics: Autism & Attention deficit hyperactivity disorder. The author has an hindex of 36, co-authored 77 publications receiving 7179 citations. Previous affiliations of Sarah Curran include Sussex Partnership NHS Foundation Trust & Brighton and Sussex Medical School.
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Journal ArticleDOI
Behavioral signatures related to genetic disorders in autism
Hilgo Bruining,Marinus J.C. Eijkemans,Martien J H Kas,Sarah Curran,Jacob A. S. Vorstman,Patrick Bolton +5 more
TL;DR: SVM algorithms may be used to stratify idiopathic cases of ASD according to behavioral signature patterns associated with genetic disorders, and the results suggest a new approach for disentangling the heterogeneity of ASD.
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Continuity and change in preschool ADHD symptoms: longitudinal genetic analysis with contrast effects.
Thomas S. Price,Emily Simonoff,Philip Asherson,Sarah Curran,Jonna Kuntsi,Irwin D. Waldman,Robert Plomin +6 more
TL;DR: A common pathway model provided the best fit to the longitudinal data, indicating that genetic influences underlie 91% of the stable variance in ADHD symptomatology, and what is stable for ADHD symptoms is largely genetic.
Journal ArticleDOI
Methyl‐CpG‐binding protein 2 polymorphisms and vulnerability to autism
Caroline S. Loat,Sarah Curran,Cathryn M. Lewis,J. Duvall,Daniel H. Geschwind,Patrick Bolton,Ian W. Craig +6 more
TL;DR: Analysis of polymorphic markers spanning the gene and comprising both microsatellites and single nucleotide polymorphisms by the transmission disequilibrium test suggests that one or more functional variants of MECP2 existing at significant frequencies in the population may confer increased risk of autism/autism spectrum disorders and warrants further investigation.
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QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms
Sarah Curran,Jonathan Mill,Pak C. Sham,Fruhling Rijsdijk,K Marusic,Eric Taylor,Philip Asherson +6 more
TL;DR: A dimensional perspective of ADHD is taken and a significant relationship between DRD4-7 and high-scoring individuals is found in a sample of children selected from the general population on the basis of high and low scores on the five ADHD items of the Strengths and Difficulties Questionnaire (SDQ).
Journal ArticleDOI
TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport
Miriam Schmidts,Yuqing Hou,Claudio Cortes,Dorus A. Mans,Céline Huber,Karsten Boldt,Mitali P. Patel,Jeroen van Reeuwijk,Jean-Marc Plaza,Sylvia E. C. van Beersum,Zhi Min Yap,Stef J.F. Letteboer,S. Paige Taylor,Warren Herridge,Colin A. Johnson,Peter J. Scambler,Marius Ueffing,Hülya Kayserili,Deborah Krakow,Stephen M. King,Philip L. Beales,Lihadh Al-Gazali,Carol Wicking,Valérie Cormier-Daire,Ronald Roepman,Hannah M. Mitchison,George B. Witman,Saeed Al-Turki,Carl A. Anderson,Richard Anney,Dinu Antony,Jennifer L. Asimit,Mohammad Ayub,Jeffrey C. Barrett,Inês Barroso,Jamie Bentham,Shoumo Bhattacharya,Douglas Blackwood,Martin Bobrow,Elena G. Bochukova,Patrick Bolton,Chris Boustred,Gerome Breen,Marie-Jo Brion,Andrew Brown,Mattia Calissano,Keren J. Carss,Krishna Chatterjee,Lu Chen,Sebhattin Cirak,Peter Clapham,Gail Clement,Guy Coates,David A. Collier,Catherine Cosgrove,Tony Cox,Nicholas John Craddock,Lucy Crooks,Sarah Curran,Allan Daly,Petr Danecek,George Davey Smith,Aaron G. Day-Williams,Ian N. M. Day,Richard Durbin,Sarah Edkins,Peter R. Ellis,David M. Evans,I. Sadaf Farooqi,Ghazaleh Fatemifar,David R. FitzPatrick,Paul Flicek,Jamie Floyd,A. Reghan Foley,Chris S Franklin,Marta Futema,Louise Gallagher,Tom R. Gaunt,Daniel H. Geschwind,Celia M. T. Greenwood,Detelina Grozeva,Xiaosen Guo,Hugh Gurling,Deborah J. Hart,Audrey E. Hendricks,Peter Holmans,Jie Huang,Steve E. Humphries,Matthew E. Hurles,Pirro G. Hysi,David A. Jackson,Yalda Jamshidi,David Jewell,Joyce Chris,Jane Kaye,Thomas M. Keane,John P. Kemp,Karen Kennedy,Alastair Kent,Anja Kolb-Kokocinski,Genevieve Lachance,Cordelia Langford,Irene Lee,Rui Li,Yingrui Li,Liu Ryan,Jouko Lönnqvist,Margarida C. Lopes,Daniel G. MacArthur,Mangino Massimo,Jonathan Marchini,John Maslen,Shane A. McCarthy,Peter McGuffin,Andrew M. McIntosh,Andrew McKechanie,Andrew McQuillin,Yasin Memari,Sarah Metrustry,J L Min,Alireza Moayyeri,James Morris,Dawn Muddyman,Francesco Muntoni,Kate Northstone,Michael Conlon O'Donovan,Stephen O'Rahilly,Alexandros Onoufriadis,Karim Oualkacha,Michael John Owen,Aarno Palotie,Kalliope Panoutsopoulou,Victoria E. R. Parker,Jeremy R. Parr,Lavinia Paternoster,Tiina Paunio,Felicity Payne,John Perry,Olli Pietiläinen,Vincent Plagnol,Michael A. Quail,Lydia Quaye,Lucy Raymond,Karola Rehnström,J. Brent Richards,Susan M. Ring,Graham R S Ritchie,David B. Savage,Nadia Schoenmakers,Robert K. Semple,Eva Goncalves Serra,Hashem A. Shihab,So-Youn Shin,David Skuse,Kerrin S. Small,Carol Smee,Artigas María Soler,Nicole Soranzo,Lorraine Southam,Tim D. Spector,Beate St Pourcain,David St Clair,Jim Stalker,Gabriela L. Surdulescu,Jaana Suvisaari,Ioanna Tachmazidou,Jing Tian,Nic Timpson,Martin D. Tobin,Ana M. Valdes,Margriet van Kogelenberg,Parthiban Vijayarangakannan,Louise V. Wain,Klaudia Walter,Jun Wang,Kirsten J. Ward,Ellie Wheeler,Ros Whittall,Hywel Williams,Kathy Williamson,Scott Wilson,Kim Wong,Tamieka Whyte,Xu ChangJiang,Eleftheria Zeggini,Feng Zhang,Hou-Feng Zheng +186 more
TL;DR: TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance are identified and defined as an integral component of the evolutionarily conserved retrograde IFT machinery.