S
Sarah Curran
Researcher at King's College London
Publications - 78
Citations - 7948
Sarah Curran is an academic researcher from King's College London. The author has contributed to research in topics: Autism & Attention deficit hyperactivity disorder. The author has an hindex of 36, co-authored 77 publications receiving 7179 citations. Previous affiliations of Sarah Curran include Sussex Partnership NHS Foundation Trust & Brighton and Sussex Medical School.
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Journal ArticleDOI
Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B.
Jonathan Mill,Xiaohui Xu,Angelica Ronald,Sarah Curran,Thomas S. Price,Jo Knight,Ian W. Craig,Pak C. Sham,Robert Plomin,Philip Asherson +9 more
TL;DR: There is some evidence to suggest that the DAT1 3′UTR VNTR and weak evidence that a microsatellite in SNAP‐25 may have a role in continuous measures of ADHD‐symptoms hyperactivity above and beyond their role in clinical ADHD.
Journal ArticleDOI
Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD
TL;DR: Overall the data provide some evidence for a role of this gene in ADHD, although the precise causal functional variant is yet to be ascertained.
Journal ArticleDOI
Association of DRD4 in children with ADHD and comorbid conduct problems.
Jane Holmes,Antony Payton,Jennifer H. Barrett,Richard Harrington,Peter McGuffin,Michael John Owen,William E R Ollier,Jane Worthington,Michael Gill,Aiveen Kirley,Ziarih Hawi,Michael Fitzgerald,Philip Asherson,Sarah Curran,John Mill,A Gould,Eric Taylor,Lyndsey Kent,Nicholas John Craddock,Anita Thapar +19 more
TL;DR: T analysis, which had previously yielded negative results for the total sample, showed evidence of association between DRD4 and "ADHD with conduct problems" (7 repeat allele-24 transmissions, 13 non-transmissions; one-tailed P=0.05).
Journal ArticleDOI
Male-Biased Autosomal Effect of 16p13.11 Copy Number Variation in Neurodevelopmental Disorders
Maria Tropeano,Joo Wook Ahn,Richard Dobson,Gerome Breen,James Rucker,Abhishek Dixit,Deb K. Pal,Peter McGuffin,Anne Farmer,Peter White,Joris Andrieux,Evangelos Vassos,Caroline Mackie Ogilvie,Sarah Curran,David A. Collier,David A. Collier +15 more
TL;DR: The data confirm that duplications and deletions at 16p13.11 represent incompletely penetrant pathogenic mutations that predispose to a range of neurodevelopmental disorders, and suggest a sex-limited effect on the penetrance of the pathological phenotypes at the 16p 13.11 locus.
Journal ArticleDOI
Common variant at 16p11.2 conferring risk of psychosis
Stacy Steinberg,S de Jong,Manuel Mattheisen,Manuel Mattheisen,Javier Costas,Ditte Demontis,Ditte Demontis,Stéphane Jamain,Olli Pietiläinen,Olli Pietiläinen,Kuang Lin,Sergi Papiol,Sergi Papiol,Johanna Huttenlocher,Engilbert Sigurdsson,Evangelos Vassos,Ina Giegling,René Breuer,Gillian Fraser,Neil Walker,Ingrid Melle,Srdjan Djurovic,Ingrid Agartz,Annamari Tuulio-Henriksson,Jaana Suvisaari,Jouko Lönnqvist,Tiina Paunio,Line Olsen,Thomas Hansen,Andres Ingason,Matti Pirinen,E Strengman,David M. Hougaard,Torben F. Ørntoft,M Didriksen,M V Hollegaard,Merete Nordentoft,Merete Nordentoft,L Abramova,Kaleda Vg,Manuel Arrojo,Julio Sanjuán,Celso Arango,Bruno Etain,Frank Bellivier,Alexandre Méary,F. Schürhoff,Andrei Szöke,Michele Ribolsi,Valentina Magni,Alberto Siracusano,Swetlana Sperling,Moritz J. Rossner,Moritz J. Rossner,Claus Christiansen,Lambertus A. Kiemeney,Barbara Franke,L.H. van den Berg,Jan H. Veldink,Sarah Curran,Patrick Bolton,M Poot,Wouter G. Staal,Karola Rehnström,Karola Rehnström,Helena Kilpinen,Helena Kilpinen,Christine M. Freitag,Jobst Meyer,Patrik K. E. Magnusson,Evald Saemundsen,I Martsenkovsky,I Bikshaieva,I Martsenkovska,O Vashchenko,M Raleva,K Paketchieva,B Stefanovski,Naser Durmishi,M. Pejovic Milovancevic,D. Lecic Tosevski,Teimuraz Silagadze,N Naneishvili,N Mikeladze,Simon Surguladze,John B. Vincent,Anne Farmer,Philip B. Mitchell,Philip B. Mitchell,Adam Wright,Adam Wright,Peter R. Schofield,Peter R. Schofield,Janice M. Fullerton,Janice M. Fullerton,Grant W. Montgomery,Nicholas G. Martin,Ivo Alex Rubino,R. van Winkel,R. van Winkel,Gunter Kenis,M. De Hert,János Réthelyi,István Bitter,Lars Terenius,Erik G. Jönsson,S Bakker,J. Van Os,Assen Jablensky,Marion Leboyer,Elvira Bramon,John Powell,Robin M. Murray,Aiden Corvin,Michael Gill,Derek W. Morris,F A O'Neill,Kenneth S. Kendler,Brien P. Riley,Nicholas John Craddock,Michael John Owen,Michael Conlon O'Donovan,Unnur Thorsteinsdottir,Augustine Kong,Hannelore Ehrenreich,Hannelore Ehrenreich,Angel Carracedo,V Golimbet,Ole A. Andreassen,Anders D. Børglum,Anders D. Børglum,Anders D. Børglum,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Thomas Werge,Thomas Werge,Roel A. Ophoff,Roel A. Ophoff,Markus M. Nöthen,Marcella Rietschel,Sven Cichon,Mirella Ruggeri,Sarah Tosato,Aarno Palotie,D St Clair,Dan Rujescu,David A. Collier,Hreinn Stefansson,Kari Stefansson +150 more
TL;DR: Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association with schizophrenia and is located within a 593-kb region that substantially increases risk of psychosis when duplicated.