S
Satoshi Shiba
Researcher at Juntendo University
Publications - 26
Citations - 1957
Satoshi Shiba is an academic researcher from Juntendo University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 9, co-authored 19 publications receiving 956 citations.
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Journal ArticleDOI
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Jakob Wirbel,Paul Theodor Pyl,Paul Theodor Pyl,Ece Kartal,Konrad Zych,Alireza Kashani,Alessio Milanese,Jonas S. Fleck,Anita Y. Voigt,Albert Pallejà,Ruby Ponnudurai,Shinichi Sunagawa,Luis Pedro Coelho,Petra Schrotz-King,Emily Vogtmann,Nina Habermann,Emma Niméus,Andrew Maltez Thomas,Andrew Maltez Thomas,Paolo Manghi,Sara Gandini,Davide Serrano,Sayaka Mizutani,Sayaka Mizutani,Hirotsugu Shiroma,Satoshi Shiba,Tatsuhiro Shibata,Shinichi Yachida,Takuji Yamada,Takuji Yamada,Levi Waldron,Alessio Naccarati,Nicola Segata,Rashmi Sinha,Cornelia M. Ulrich,Hermann Brenner,Manimozhiyan Arumugam,Manimozhiyan Arumugam,Peer Bork,Georg Zeller +39 more
TL;DR: A meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer identified a core set of 29 species significantly enriched in CRC metagenomes, establishing globally generalizable, predictive taxonomic and functional microbiome CRC signatures as a basis for future diagnostics.
Journal ArticleDOI
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer
Shinichi Yachida,Sayaka Mizutani,Hirotsugu Shiroma,Satoshi Shiba,Takeshi Nakajima,Taku Sakamoto,Hikaru Watanabe,Keigo Masuda,Yuichiro Nishimoto,Masaru Kubo,Fumie Hosoda,Hirofumi Rokutan,Minori Matsumoto,Hiroyuki Takamaru,Masayoshi Yamada,Takahisa Matsuda,Motoki Iwasaki,Taiki Yamaji,Tatsuo Yachida,Tomoyoshi Soga,Ken Kurokawa,Atsushi Toyoda,Yoshitoshi Ogura,Tetsuya Hayashi,Masanori Hatakeyama,Hitoshi Nakagama,Yutaka Saito,Shinji Fukuda,Tatsuhiro Shibata,Takuji Yamada,Takuji Yamada +30 more
TL;DR: Large-cohort multi-omics data indicate that shifts in the microbiome and metabolome occur from the very early stages of the development of colorectal cancer, which is of possible etiological and diagnostic importance.
Journal ArticleDOI
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation
Andrew Maltez Thomas,Andrew Maltez Thomas,Paolo Manghi,Francesco Asnicar,Edoardo Pasolli,Federica Armanini,Moreno Zolfo,Francesco Beghini,Serena Manara,Nicolai Karcher,Chiara Pozzi,Sara Gandini,Davide Serrano,Sonia Tarallo,Antonio Francavilla,Gaetano Gallo,Mario Trompetto,Giulio Ferrero,Sayaka Mizutani,Sayaka Mizutani,Hirotsugu Shiroma,Satoshi Shiba,Tatsuhiro Shibata,Shinichi Yachida,Takuji Yamada,Takuji Yamada,Jakob Wirbel,Petra Schrotz-King,Cornelia M. Ulrich,Hermann Brenner,Manimozhiyan Arumugam,Manimozhiyan Arumugam,Peer Bork,Georg Zeller,Francesca Cordero,Emmanuel Dias-Neto,João C. Setubal,João C. Setubal,Adrian Tett,Barbara Pardini,Maria Rescigno,Levi Waldron,Alessio Naccarati,Nicola Segata +43 more
TL;DR: The combined analysis of heterogeneous CRC cohorts identified reproducible microbiome biomarkers and accurate disease-predictive models that can form the basis for clinical prognostic tests and hypothesis-driven mechanistic studies.
Journal ArticleDOI
Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles
Pande Putu Erawijantari,Sayaka Mizutani,Sayaka Mizutani,Hirotsugu Shiroma,Satoshi Shiba,Takeshi Nakajima,Taku Sakamoto,Yutaka Saito,Shinji Fukuda,Shinichi Yachida,Takuji Yamada +10 more
TL;DR: The results reveal alterations of gut microbiota after gastrectomy, suggesting its association with postoperative comorbidities, and the multi-omic approach applied in this study could complement the follow-up of patients after Gastrectomy.
Journal ArticleDOI
Multicenter retrospective analysis of systemic chemotherapy for unresectable combined hepatocellular and cholangiocarcinoma
Satoshi Kobayashi,Takeshi Terashima,Satoshi Shiba,Yukio Yoshida,Ikuhiro Yamada,Shouta Iwadou,Shigeru Horiguchi,Hideaki Takahashi,Eiichiro Suzuki,Michihisa Moriguchi,Kunihiro Tsuji,Taiga Otsuka,Akinori Asagi,Yasushi Kojima,Ryoji Takada,Chigusa Morizane,Nobumasa Mizuno,Masafumi Ikeda,Makoto Ueno,Junji Furuse +19 more
TL;DR: The platinum‐containing regimens such as gemcitabine/cisplatin were associated with more favorable outcomes than sorafenib monotherapy for unresectable combined hepatocellular and cholangiocarcinoma.