S
Sebastian Hoersch
Researcher at Massachusetts Institute of Technology
Publications - 38
Citations - 6824
Sebastian Hoersch is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Alternative splicing & Cancer. The author has an hindex of 25, co-authored 38 publications receiving 5651 citations. Previous affiliations of Sebastian Hoersch include Novartis & European Bioinformatics Institute.
Papers
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Journal ArticleDOI
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie,Pablo Tamayo,Jesse S. Boehm,So Young Kim,Susan Moody,Ian F. Dunn,Anna C. Schinzel,Peter Sandy,Etienne Meylan,Claudia Scholl,Stefan Fröhling,Edmond M. Chan,Martin L. Sos,Kathrin Michel,Craig H. Mermel,Serena J. Silver,Barbara A. Weir,Jan H. Reiling,Qing Sheng,Piyush Gupta,Raymond C. Wadlow,Raymond C. Wadlow,Hanh Le,Sebastian Hoersch,Ben S. Wittner,Ben S. Wittner,Sridhar Ramaswamy,Sridhar Ramaswamy,David M. Livingston,David M. Sabatini,Matthew Meyerson,Matthew Meyerson,Roman K. Thomas,Eric S. Lander,Jill P. Mesirov,David E. Root,D. Gary Gilliland,Tyler Jacks,William C. Hahn +38 more
TL;DR: Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.
Journal ArticleDOI
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
Alexandra Naba,Karl R. Clauser,Sebastian Hoersch,Sebastian Hoersch,Hui Liu,Steven A. Carr,Richard O. Hynes +6 more
TL;DR: A proteomic strategy developed to characterize the in vivo ECM composition of normal tissues and tumors using enrichment of protein extracts for ECM components and subsequent analysis by mass spectrometry and a bioinformatic approach to predict the in silico “matrisome” defined as the ensemble of ECM proteins and associated factors are presented.
Journal ArticleDOI
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna Murthi Vasudevan,David A. Barbie,David A. Barbie,Michael A. Davies,Rosalia Rabinovsky,Chontelle J. McNear,Jessica J. Kim,Bryan T. Hennessy,Hsiuyi Tseng,Panisa Pochanard,So Young Kim,So Young Kim,Ian F. Dunn,Anna C. Schinzel,Anna C. Schinzel,Peter Sandy,Sebastian Hoersch,Qing Sheng,Piyush Gupta,Jesse S. Boehm,Jan H. Reiling,Serena J. Silver,Yiling Lu,Katherine Stemke-Hale,Bhaskar Dutta,Corwin Joy,Aysegul A. Sahin,Ana M. Gonzalez-Angulo,Ana Lluch,Lucia E. Rameh,Tyler Jacks,David E. Root,Eric S. Lander,Gordon B. Mills,William C. Hahn,William R. Sellers,William R. Sellers,Levi A. Garraway +37 more
TL;DR: This paper showed that SGK3 undergoes PI3K-and PDK1-dependent activation in PIK3CA mutant cancer cells and showed that these cells retain robust PDK 1 activation and membrane localization and exhibit dependency on the SGK 1 substrate SGK 3.
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna Murthi Vasudevan,David A. Barbie,David A. Barbie,Michael A. Davies,Rosalia Rabinovsky,Chontelle J. McNear,Jessica J. Kim,Bryan T. Hennessy,Hsiuyi Tseng,Panisa Pochanard,So Young Kim,So Young Kim,Ian F. Dunn,Anna C. Schinzel,Anna C. Schinzel,Peter Sandy,Sebastian Hoersch,Qing Sheng,Piyush Gupta,Jesse S. Boehm,Jan H. Reiling,Serena J. Silver,Yiling Lu,Katherine Stemke-Hale,Bhaskar Dutta,Corwin Joy,Aysegul A. Sahin,Ana M. Gonzalez-Angulo,Ana Lluch,Lucia E. Rameh,Tyler Jacks,David E. Root,Eric S. Lander,Gordon B. Mills,William C. Hahn,William R. Sellers,William R. Sellers,Levi A. Garraway +37 more
TL;DR: It is shown through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth.
Patent
Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
Robert Schlegel,Yan Chen,Xumei Zhao,John Monahan,Shubhangi Kamatkar,Manjula Gannavarapu,Karen Glatt,Sebastian Hoersch +7 more
TL;DR: In this article, newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia are described. But none of the methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.