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Jan H. Reiling

Researcher at University of Texas MD Anderson Cancer Center

Publications -  23
Citations -  7063

Jan H. Reiling is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Golgi apparatus & Brefeldin A. The author has an hindex of 17, co-authored 20 publications receiving 5178 citations. Previous affiliations of Jan H. Reiling include Broad Institute & University of Zurich.

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, +38 more
- 05 Nov 2009 - 
TL;DR: Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.
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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, +9 more
- 01 Dec 2004 - 
TL;DR: It is shown that mTOR inhibition by hypoxia requires the TSC1/TSC2 tumor suppressor complex and the Hypoxia-inducible gene REDD1/RTP801 to be inhibited, and that down-regulation of mTOR activity by hyp oxia requires de novo mRNA synthesis and correlates with increased expression of the hypoxIA-Inducible REDD 1 gene.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

Krishna Murthi Vasudevan, +37 more
- 07 Jul 2009 - 
TL;DR: This paper showed that SGK3 undergoes PI3K-and PDK1-dependent activation in PIK3CA mutant cancer cells and showed that these cells retain robust PDK 1 activation and membrane localization and exhibit dependency on the SGK 1 substrate SGK 3.

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

Krishna Murthi Vasudevan, +37 more
TL;DR: It is shown through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth.