E
Edmond M. Chan
Researcher at Harvard University
Publications - 8
Citations - 3110
Edmond M. Chan is an academic researcher from Harvard University. The author has contributed to research in topics: Microsatellite instability & DNA mismatch repair. The author has an hindex of 5, co-authored 8 publications receiving 2153 citations. Previous affiliations of Edmond M. Chan include Broad Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie,Pablo Tamayo,Jesse S. Boehm,So Young Kim,Susan Moody,Ian F. Dunn,Anna C. Schinzel,Peter Sandy,Etienne Meylan,Claudia Scholl,Stefan Fröhling,Edmond M. Chan,Martin L. Sos,Kathrin Michel,Craig H. Mermel,Serena J. Silver,Barbara A. Weir,Jan H. Reiling,Qing Sheng,Piyush Gupta,Raymond C. Wadlow,Raymond C. Wadlow,Hanh Le,Sebastian Hoersch,Ben S. Wittner,Ben S. Wittner,Sridhar Ramaswamy,Sridhar Ramaswamy,David M. Livingston,David M. Sabatini,Matthew Meyerson,Matthew Meyerson,Roman K. Thomas,Eric S. Lander,Jill P. Mesirov,David E. Root,D. Gary Gilliland,Tyler Jacks,William C. Hahn +38 more
TL;DR: Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.
Journal ArticleDOI
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Edmond M. Chan,Edmond M. Chan,Tsukasa Shibue,James M. McFarland,Benjamin Gaeta,Mahmoud Ghandi,Nancy Dumont,Alfredo Gonzalez,Justine S. McPartlan,Tianxia Li,Yanxi Zhang,Jie Bin Liu,Jean-Bernard Lazaro,Peili Gu,Cortt G. Piett,Annie Apffel,Syed O. Ali,Syed O. Ali,Rebecca Deasy,Paula Keskula,Raymond W.S. Ng,Raymond W.S. Ng,Emma A. Roberts,Elizaveta Reznichenko,Lisa Leung,Maria Alimova,Monica Schenone,Mirazul Islam,Mirazul Islam,Yosef E. Maruvka,Yosef E. Maruvka,Yang Liu,Yang Liu,Jatin Roper,Srivatsan Raghavan,Srivatsan Raghavan,Marios Giannakis,Marios Giannakis,Yuen-Yi Tseng,Zachary D. Nagel,Zachary D. Nagel,Alan D. D'Andrea,David E. Root,Jesse S. Boehm,Gad Getz,Gad Getz,Sandy Chang,Todd R. Golub,Todd R. Golub,Todd R. Golub,Aviad Tsherniak,Francisca Vazquez,Francisca Vazquez,Adam J. Bass,Adam J. Bass +54 more
TL;DR: Data from large-scale silencing screens using CRISPR–Cas9-mediated knockout and RNA interference found that the RecQ DNA helicase WRN was selectively essential in MSI models in vitro and in vivo, yet dispensable in models of cancers that are microsatellite stable.
Journal ArticleDOI
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit
Zehua Zhu,Amir Reza Aref,Travis J. Cohoon,Thanh U. Barbie,Yu Imamura,Shenghong Yang,Susan Moody,Rhine R. Shen,Anna C. Schinzel,Tran C. Thai,Jacob B. Reibel,Pablo Tamayo,Jason T. Godfrey,Zhi Rong Qian,Asher N. Page,Karolina Maciag,Edmond M. Chan,Whitney Silkworth,Mary T. Labowsky,Lior Rozhansky,Jill P. Mesirov,William E. Gillanders,Shuji Ogino,Nir Hacohen,Suzanne Gaudet,Michael J. Eck,Jeffrey A. Engelman,Ryan B. Corcoran,Kwok-Kin Wong,William C. Hahn,David A. Barbie +30 more
TL;DR: It is shown that the IκB kinase (IKK)-related kinases Tank-binding kinase-1 (TBK1) and IKKε promote KRAS-driven tumorigenesis by regulating autocrine CCL5 and interleukin (IL)-6 and CYT387 as a potent JAK/TBK 1/IKKε inhibitor is identified.
Journal ArticleDOI
Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Daqi Tu,Zehua Zhu,Zehua Zhu,Alicia Y. Zhou,Alicia Y. Zhou,Cai-Hong Yun,Kyung-Eun Lee,Angela V. Toms,Yiqun Li,Gavin P. Dunn,Gavin P. Dunn,Edmond M. Chan,Edmond M. Chan,Tran C. Thai,Tran C. Thai,Shenghong Yang,Shenghong Yang,Scott B. Ficarro,Jarrod A. Marto,Hyesung Jeon,William C. Hahn,William C. Hahn,David A. Barbie,David A. Barbie,Michael J. Eck +24 more
TL;DR: The 2.4 Å-resolution crystal structure of nearly full-length TBK1 in complex with specific inhibitors is described, revealing a dimeric assembly created by an extensive network of interactions among the kinase, ubiquitin-like, and scaffold/dimerization domains.
Journal ArticleDOI
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Niek van Wietmarschen,Sriram Sridharan,William J. Nathan,Anthony T. Tubbs,Edmond M. Chan,Edmond M. Chan,Elsa Callen,Wei Wu,Frida Belinky,Veenu Tripathi,Nancy Wong,Kyla Foster,Javad Noorbakhsh,Kiran V. Garimella,Abimael Cruz-Migoni,Joshua A. Sommers,Yongqing Huang,Ashir A. Borah,Jonathan T. Smith,Jeremie Kalfon,Nikolas Kesten,Kasper Fugger,Robert L. Walker,Egor Dolzhenko,Michael A. Eberle,Bruce E. Hayward,Karen Usdin,Catherine H. Freudenreich,Robert M. Brosh,Stephen C. West,Peter J. McHugh,Paul S. Meltzer,Adam J. Bass,Adam J. Bass,André Nussenzweig +34 more
TL;DR: It is shown that TA-dinucleotide repeats are highly unstable in MSI cells and undergo large-scale expansions, distinct from previously described insertion or deletion mutations of a few nucleotides, and support the development of therapeutic agents that target WRN for MSI-associated cancers.