Deep learning is a form of machine learning that enables computers to learn from experience and understand the world in terms of a hierarchy of concepts. Because the computer gathers knowledge from experience, there is no need for a human computer operator to formally specify all the knowledge that the computer needs. The hierarchy of concepts allows the computer to learn complicated concepts by building them out of simpler ones; a graph of these hierarchies would be many layers deep. This book introduces a broad range of topics in deep learning. The text offers mathematical and conceptual background, covering relevant concepts in linear algebra, probability theory and information theory, numerical computation, and machine learning. It describes deep learning techniques used by practitioners in industry, including deep feedforward networks, regularization, optimization algorithms, convolutional networks, sequence modeling, and practical methodology; and it surveys such applications as natural language processing, speech recognition, computer vision, online recommendation systems, bioinformatics, and videogames. Finally, the book offers research perspectives, covering such theoretical topics as linear factor models, autoencoders, representation learning, structured probabilistic models, Monte Carlo methods, the partition function, approximate inference, and deep generative models. Deep Learning can be used by undergraduate or graduate students planning careers in either industry or research, and by software engineers who want to begin using deep learning in their products or platforms. A website offers supplementary material for both readers and instructors.

Deep Learning

We describe latent Dirichlet allocation (LDA), a generative probabilistic model for collections of discrete data such as text corpora. LDA is a three-level hierarchical Bayesian model, in which each item of a collection is modeled as a finite mixture over an underlying set of topics. Each topic is, in turn, modeled as an infinite mixture over an underlying set of topic probabilities. In the context of text modeling, the topic probabilities provide an explicit representation of a document. We present efficient approximate inference techniques based on variational methods and an EM algorithm for empirical Bayes parameter estimation. We report results in document modeling, text classification, and collaborative filtering, comparing to a mixture of unigrams model and the probabilistic LSI model.

/pdf/latent-dirichlet-allocation-4gmscb06en.pdf

Latent dirichlet allocation

We propose a generative model for text and other collections of discrete data that generalizes or improves on several previous models including naive Bayes/unigram, mixture of unigrams [6], and Hof-mann's aspect model, also known as probabilistic latent semantic indexing (pLSI) [3]. In the context of text modeling, our model posits that each document is generated as a mixture of topics, where the continuous-valued mixture proportions are distributed as a latent Dirichlet random variable. Inference and learning are carried out efficiently via variational algorithms. We present empirical results on applications of this model to problems in text modeling, collaborative filtering, and text classification.

/pdf/latent-dirichlet-allocation-rkwbqihm3p.pdf

Latent Dirichlet Allocation

Data Mining: Practical Machine Learning Tools and Techniques offers a thorough grounding in machine learning concepts as well as practical advice on applying machine learning tools and techniques in real-world data mining situations. This highly anticipated third edition of the most acclaimed work on data mining and machine learning will teach you everything you need to know about preparing inputs, interpreting outputs, evaluating results, and the algorithmic methods at the heart of successful data mining. Thorough updates reflect the technical changes and modernizations that have taken place in the field since the last edition, including new material on Data Transformations, Ensemble Learning, Massive Data Sets, Multi-instance Learning, plus a new version of the popular Weka machine learning software developed by the authors. Witten, Frank, and Hall include both tried-and-true techniques of today as well as methods at the leading edge of contemporary research. *Provides a thorough grounding in machine learning concepts as well as practical advice on applying the tools and techniques to your data mining projects *Offers concrete tips and techniques for performance improvement that work by transforming the input or output in machine learning methods *Includes downloadable Weka software toolkit, a collection of machine learning algorithms for data mining tasks-in an updated, interactive interface. Algorithms in toolkit cover: data pre-processing, classification, regression, clustering, association rules, visualization

Data Mining: Practical Machine Learning Tools and Techniques

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We introduce the SCAPE method (Shape Completion and Animation for PEople)---a data-driven method for building a human shape model that spans variation in both subject shape and pose. The method is based on a representation that incorporates both articulated and non-rigid deformations. We learn a pose deformation model that derives the non-rigid surface deformation as a function of the pose of the articulated skeleton. We also learn a separate model of variation based on body shape. Our two models can be combined to produce 3D surface models with realistic muscle deformation for different people in different poses, when neither appear in the training set. We show how the model can be used for shape completion --- generating a complete surface mesh given a limited set of markers specifying the target shape. We present applications of shape completion to partial view completion and motion capture animation. In particular, our method is capable of constructing a high-quality animated surface model of a moving person, with realistic muscle deformation, using just a single static scan and a marker motion capture sequence of the person.

/pdf/scape-shape-completion-and-animation-of-people-2tnl8cqmkm.pdf

SCAPE: shape completion and animation of people

To navigate reliably in indoor environments, a mobile robot must know where it is. Thus, reliable position estimation is a key problem in mobile robotics. We believe that probabilistic approaches are among the most promising candidates to providing a comprehensive and real-time solution to the robot localization problem. However, current methods still face considerable hurdles. In particular the problems encountered are closely related to the type of representation used to represent probability densities over the robot's state space. Earlier work on Bayesian filtering with particle-based density representations opened up a new approach for mobile robot localization based on these principles. We introduce the Monte Carlo localization method, where we represent the probability density involved by maintaining a set of samples that are randomly drawn from it. By using a sampling-based representation we obtain a localization method that can represent arbitrary distributions. We show experimentally that the resulting method is able to efficiently localize a mobile robot without knowledge of its starting location. It is faster, more accurate and less memory-intensive than earlier grid-based methods,.

/pdf/monte-carlo-localization-for-mobile-robots-5388342b77.pdf

Monte Carlo localization for mobile robots

This article provides a comprehensive introduction into the field of robotic mapping, with a focus on indoor mapping. It describes and compares various probabilistic techniques, as they are presently being applied to a vast array of mobile robot mapping problems. The history of robotic mapping is also detailed, along with an extensive list of open research problems.

/pdf/robotic-mapping-a-survey-4m18o2pjhn.pdf

Robotic mapping: a survey

Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, we show that substrate elasticity is a potent regulator of MuSC fate in culture. Unlike MuSCs on rigid plastic dishes (approximately 10(6) kilopascals), MuSCs cultured on soft hydrogel substrates that mimic the elasticity of muscle (12 kilopascals) self-renew in vitro and contribute extensively to muscle regeneration when subsequently transplanted into mice and assayed histologically and quantitatively by noninvasive bioluminescence imaging. Our studies provide novel evidence that by recapitulating physiological tissue rigidity, propagation of adult muscle stem cells is possible, enabling future cell-based therapies for muscle-wasting diseases.

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

Preface. Part I: Overview Articles. 1. Learning to Learn: Introduction and Overview S. Thrun, L. Pratt. 2. A Survey of Connectionist Network Reuse Through Transfer L. Pratt, B. Jennings. 3. Transfer in Cognition A. Robins. Part II: Prediction. 4. Theoretical Models of Learning to Learn J. Baxter. 5. Multitask Learning R. Caruana. 6. Making a Low-Dimensional Representation Suitable for Diverse Tasks N. Intrator, S. Edelman. 7. The Canonical Distortion Measure for Vector Quantization and Function Approximation J. Baxter. 8. Lifelong Learning Algorithms S. Thrun. Part III: Relatedness. 9. The Parallel Transfer of Task Knowledge Using Dynamic Learning Rates Based on a Measure of Relatedness D.L. Silver, R.E. Mercer. 10. Clustering Learning Tasks and the Selective Cross-Task Transfer of Knowledge S. Thrun, J. O'Sullivan. Part IV: Control. 11. CHILD: A First Step Towards Continual Learning M.B. Ring. 12. Reinforcement Learning with Self-Modifying Policies J. Schmidhuber, et al. 13. Creating Advice-Taking Reinforcement Learners R. Maclin, J.W. Shavlik. Contributing Authors. Index.

Sebastian Thrun

Papers

SCAPE: shape completion and animation of people

Monte Carlo localization for mobile robots

Robotic mapping: a survey

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

Learning to learn