S
Sébastien Bonnet
Researcher at Laval University
Publications - 195
Citations - 12429
Sébastien Bonnet is an academic researcher from Laval University. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 54, co-authored 171 publications receiving 10254 citations. Previous affiliations of Sébastien Bonnet include University of Alberta & French Institute of Health and Medical Research.
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Journal ArticleDOI
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
Journal ArticleDOI
Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives.
Marc Humbert,Marc Humbert,Christophe Guignabert,Christophe Guignabert,Sébastien Bonnet,Peter Dorfmüller,Peter Dorfmüller,James R. Klinger,Mark R. Nicolls,Andrea Olschewski,Soni Savai Pullamsetti,Soni Savai Pullamsetti,Ralph T. Schermuly,Kurt R. Stenmark,Marlene Rabinovitch +14 more
TL;DR: Recent findings in pathology and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of pulmonary hypertension are reviewed and ways to improve management and to support and optimise drug development are discussed.
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An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats Similarities to Human Pulmonary Arterial Hypertension
Sébastien Bonnet,Evangelos D. Michelakis,Christopher J. Porter,Miguel A. Andrade-Navarro,Bernard Thébaud,Sandra Bonnet,Alois Haromy,Gwyneth Harry,Rohit Moudgil,M. Sean McMurtry,E. Kenneth Weir,Stephen L. Archer +11 more
TL;DR: An intersection between oxygen-sensing mechanisms and PAH is revealed, analogous to the pathophysiology of chronically hypoxic Sprague-Dawley rats, and the mitochondria-ROS-HIF-Kv pathway offers new targets for PAH therapy.
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Role for miR-204 in human pulmonary arterial hypertension
Audrey Courboulin,Roxane Paulin,Nellie J. Giguère,Nehmé Saksouk,Tanya Perreault,Jolyane Meloche,Eric Paquet,Sabrina Biardel,Steeve Provencher,Jacques Côté,Martin J. Simard,Sébastien Bonnet +11 more
TL;DR: Reduced miR-204 expression facilitates the excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells characteristic of human pulmonary arterial hypertension.
Journal ArticleDOI
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
M. Sean McMurtry,Sébastien Bonnet,Xichen Wu,Jason R.B. Dyck,Alois Haromy,Kyoko Hashimoto,Evangelos D. Michelakis +6 more
TL;DR: It is shown that dichloroacetate (DCA), a metabolic modulator that increases mitochondrial oxidative phosphorylation, prevents and reverses established monocrotaline-induced PAH (MCT-PAH), significantly improving mortality.