Fei Gao

TL;DR: High-resolution lipidomic and proteomic analyses of exosomes and MVs derived by differential ultracentrifugation from 3 different cell types: U87 glioblastoma cells, Huh7 hepatocellular carcinoma cells and human bone marrow-derived mesenchymal stem cells are reported.

TL;DR: It is shown that the lipid 12, 13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a stimulator of BAT activity, and that its levels are negatively correlated with body-mass index and insulin sensitivity, and this data suggest that 12,13 -diHOME, or a functional analog, could be developed as a treatment for metabolic disorders.

TL;DR: In this article, the authors used a system vaccinology approach to comprehensively profile the innate and adaptive immune responses of 56 healthy volunteers who were vaccinated with the Pfizer-BioNTech mRNA vaccine (BNT162b2).

TL;DR: Exercise-induced changes to the scWAT and BAT lipidome are highly specific to certain molecular lipid species, indicating that changes in tissue lipid content reflect selective remodeling in scWat and BAT of both phospholipids and glycerol lipids in response to exercise training, thus providing a comprehensive resource for future studies of lipid metabolism pathways.

TL;DR: In this paper, the authors compare the magnitude and breadth of antibodies targeting SARS-CoV-2, SARS CoV2 variants of concern, and endemic coronaviruses, in vaccinees and infected patients.