V
Vamsee Mallajosyula
Researcher at Stanford University
Publications - 33
Citations - 1583
Vamsee Mallajosyula is an academic researcher from Stanford University. The author has contributed to research in topics: Hemagglutinin (influenza) & Immune system. The author has an hindex of 13, co-authored 27 publications receiving 642 citations. Previous affiliations of Vamsee Mallajosyula include Indian Institute of Science.
Papers
More filters
Journal ArticleDOI
Systems vaccinology of the BNT162b2 mRNA vaccine in humans.
Prabhu S. Arunachalam,Madeleine K D Scott,Thomas Hagan,Thomas Hagan,Chunfeng Li,Yupeng Feng,Florian Wimmers,Lilit Grigoryan,Meera Trisal,Venkata Viswanadh Edara,Lilin Lai,Sarah Esther Chang,Allan Feng,Shaurya Dhingra,Mihir Shah,Alexandra S. Lee,Sharon Chinthrajah,Sayantani B. Sindher,Vamsee Mallajosyula,Fei Gao,Natalia Sigal,Sangeeta Kowli,Sheena Gupta,Kathryn L. Pellegrini,Gregory K. Tharp,Sofia Maysel-Auslender,Sydney Hamilton,Hadj Aoued,Kevin Hrusovsky,Mark Roskey,Steven E. Bosinger,Steven E. Bosinger,Holden T. Maecker,Scott D. Boyd,Mark M. Davis,Paul J. Utz,Mehul S. Suthar,Purvesh Khatri,Kari C. Nadeau,Kari C. Nadeau,Bali Pulendran +40 more
TL;DR: In this article, the authors used a system vaccinology approach to comprehensively profile the innate and adaptive immune responses of 56 healthy volunteers who were vaccinated with the Pfizer-BioNTech mRNA vaccine (BNT162b2).
Journal ArticleDOI
Proinflammatory IgG Fc structures in patients with severe COVID-19.
Saborni Chakraborty,Joseph C. Gonzalez,Karlie Edwards,Vamsee Mallajosyula,Anthony S. Buzzanco,Robert Sherwood,Cindy Buffone,Nimish Kathale,Susan Providenza,Markus M. Xie,Jason R. Andrews,Catherine A. Blish,Upinder Singh,Haley L. Dugan,Patrick C. Wilson,Tho D. Pham,Scott D. Boyd,Kari C. Nadeau,Benjamin A. Pinsky,Sheng Zhang,Matthew J. Memoli,Jeffery K. Taubenberger,Tasha Morales,Jeffrey M. Schapiro,Gene S. Tan,Gene S. Tan,Prasanna Jagannathan,Taia T. Wang +27 more
TL;DR: It is shown that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1, and Wang and colleagues show that low levels of IgG fucOSylation enhance interactions with activating Fcγ receptors, boosting the inflammatory cytokines associated with severe COVID.
Journal ArticleDOI
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
Katharina Röltgen,Sandra C. A. Nielsen,Oscar Silva,Sheren F. Younes,M. Zaslavsky,Cristina Costales,Fan Yang,Oliver F. Wirz,Daniel Solis,Ramona A. Hoh,A. Wang,Prabhu S. Arunachalam,Deana Colburg,Shu-hua Zhao,Emily Haraguchi,Alexandra S. Lee,Mihir Shah,Monali Manohar,Iris Chang,Fei Gao,Vamsee Mallajosyula,Chunfeng Li,James Liu,Massa J. Shoura,Sayantani B. Sindher,Elizabeth Parsons,Naranjargal Dashdorj,Naranbaatar Dashdorj,R W Monroe,Geidy E. Serrano,Thomas G. Beach,R. Sharon Chinthrajah,Gregory W. Charville,James L. Wilbur,Jacob N. Wohlstadter,Mark M. Davis,Bali Pulendran,Megan L. Troxell,George Sigal,Yasodha Natkunam,Benjamin A. Pinsky,Kari C. Nadeau,Scott D. Boyd +42 more
TL;DR: In this paper , the authors investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines.
Journal ArticleDOI
Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.
Vamsee Mallajosyula,Michael P. Citron,Francesca Ferrara,Xianghan Lu,Cheryl Callahan,Gwendolyn J. Heidecker,Siddhartha P. Sarma,Jessica A. Flynn,Nigel J. Temperton,Xiaoping Liang,Raghavan Varadarajan +10 more
TL;DR: A thermotolerant, disulfide-free, and trimeric HA stem-fragment immunogen which mimics the native, prefusion conformation of HA and binds conformation specific bnAbs with high affinity is designed.
Journal ArticleDOI
Modeling human adaptive immune responses with tonsil organoids.
Lisa E. Wagar,Lisa E. Wagar,Ameen A. Salahudeen,Ameen A. Salahudeen,Christian McCrory Constantz,Ben S. Wendel,Michael Lyons,Vamsee Mallajosyula,Lauren P. Jatt,Julia Z. Adamska,Julia Z. Adamska,Lisa K. Blum,Lisa K. Blum,Neha Gupta,Katherine J. L. Jackson,Fan Yang,Katharina Röltgen,Krishna M. Roskin,Kelly M. Blaine,Kara D. Meister,Kara D. Meister,Iram N. Ahmad,Mario Cortese,Emery G. Dora,Sean N. Tucker,Anne I. Sperling,Aarti Jain,D. Huw Davies,Philip L. Felgner,Gregory B. Hammer,Peter S. Kim,William H. Robinson,William H. Robinson,Scott D. Boyd,Calvin J. Kuo,Mark M. Davis,Mark M. Davis +36 more
TL;DR: The authors used human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key germinal center features in vitro, including the production of antigen-specific antibodies, somatic hypermutation and affinity maturation, plasmablast differentiation and class-switch recombination.