Shiguo Zhou

TL;DR: The gapless genome of C. higginsianum provides access to repeat-rich regions that were previously poorly assembled and allowed prediction of the complete SM gene repertoire, and provides insights into the potential role of TEs in gene and genome evolution and host adaptation in this asexual pathogen.

TL;DR: Two whole-genome restriction maps (XhoI and PvuII) of Y. pestis strain KIM were constructed using shotgun optical mapping, showing that such maps facilitated the closure of sequence gaps and provided a purely independent means for sequence validation.

TL;DR: The sequence of chromosome II from Trypanosoma brucei, the causative agent of African sleeping sickness, is reported, suggesting that this region may be a site for modular de novo construction of VSG gene diversity during transposition/gene conversion events.

TL;DR: This work describes how optical mapping, a single-molecule system, was used to identify and annotate chromosomal alterations between bacterial strains represented by several species and suggests that genomic rearrangements and chromosomal breakpoints are readily identified and annotated against a prototypic sequenced strain by using the tools of optical mapping.

TL;DR: In this article, three whole-genome restriction endonuclease maps (XbaI, NheI, and HindIII) of R. rubrum strain ATCC 11170 were created by optical mapping.