S
Sara E. Melville
Researcher at University of Cambridge
Publications - 42
Citations - 4530
Sara E. Melville is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 23, co-authored 42 publications receiving 4315 citations.
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Journal ArticleDOI
The Genome of the African Trypanosome Trypanosoma brucei
Matthew Berriman,Elodie Ghedin,Elodie Ghedin,Christiane Hertz-Fowler,Gaëlle Blandin,Hubert Renauld,Daniella Castanheira Bartholomeu,Nicola Lennard,Elisabet Caler,N. Hamlin,Brian J. Haas,Ulrike Böhme,Linda Hannick,Martin Aslett,Joshua Shallom,Lucio Marcello,Lihua Hou,Bill Wickstead,U. Cecilia M. Alsmark,Claire Arrowsmith,Rebecca Atkin,Andrew Barron,Frédéric Bringaud,Karen Brooks,Mark Carrington,Inna Cherevach,Tracey-Jane Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Robert L. Davies,Jonathon Doggett,Appolinaire Djikeng,Tamara Feldblyum,Mark C. Field,Audrey Fraser,Ian Goodhead,Zahra Hance,David Harper,Barbara Harris,Heidi Hauser,Jessica B. Hostetler,Al Ivens,Kay Jagels,David W. Johnson,Justin Johnson,Kristine Jones,Arnaud Kerhornou,Hean Koo,Natasha Larke,Scott M. Landfear,Christopher Larkin,Vanessa Leech,Alexandra Line,Angela Lord,Annette MacLeod,P. Mooney,Sharon Moule,David M. A. Martin,Gareth W. Morgan,Karen Mungall,Halina Norbertczak,Doug Ormond,Grace Pai,Christopher S. Peacock,Jeremy Peterson,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Chris P Reitter,Steven L. Salzberg,Mandy Sanders,Seth Schobel,Sarah Sharp,Mark Simmonds,Anjana J. Simpson,Luke J. Tallon,C. Michael R. Turner,Andrew Tait,Adrian Tivey,Susan Van Aken,Danielle Walker,David Wanless,Shiliang Wang,Brian White,Owen White,Sally Whitehead,John Woodward,Jennifer R. Wortman,Mark Raymond Adams,T. Martin Embley,Keith Gull,Elisabetta Ullu,J. David Barry,Alan H. Fairlamb,Fred R. Opperdoes,Barclay G. Barrell,John E. Donelson,Neil Hall,Neil Hall,Claire M. Fraser,Sara E. Melville,Najib M. El-Sayed,Najib M. El-Sayed +104 more
TL;DR: Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Journal ArticleDOI
Comparative genomics of trypanosomatid parasitic protozoa.
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Gaëlle Blandin,Matthew Berriman,Jonathan Crabtree,Gautam Aggarwal,Elisabet Caler,Hubert Renauld,Elizabeth A. Worthey,Christiane Hertz-Fowler,Elodie Ghedin,Christopher S. Peacock,Daniella Castanheira Bartholomeu,Brian J. Haas,Anh Nhi Tran,Jennifer R. Wortman,U. Cecilia M. Alsmark,Samuel V. Angiuoli,Atashi Anupama,Jonathan H. Badger,Frédéric Bringaud,Eithon Cadag,Jane M. Carlton,Gustavo C. Cerqueira,Todd Creasy,Arthur L. Delcher,Appolinaire Djikeng,T. Martin Embley,Christopher R. Hauser,Alasdair Ivens,Sarah K. Kummerfeld,José B. Pereira-Leal,Daniel Nilsson,Jeremy Peterson,Steven L. Salzberg,Joshua Shallom,Joana C. Silva,Jaideep P. Sundaram,Scott J. Westenberger,Owen White,Sara E. Melville,John E. Donelson,Björn Andersson,Kenneth Stuart,Kenneth Stuart,Neil Hall +46 more
TL;DR: No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed.
Journal ArticleDOI
Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis.
TL;DR: STH reinfections occur rapidly after treatment, particularly for A. lumbricoides and T. trichiura, and there is a need for frequent anthelmintic drug administrations to maximize the benefit of preventive chemotherapy.
Journal ArticleDOI
The plant mitochondrial genome: homologous recombination as a mechanism for generating heterogeneity
TL;DR: It is proposed that inter- and intramolecular homologous recombination can account for the diversity of the observed genome organizations, and unequal partitioning of the cytoplasm during cell division can lead to the rapid evolution of mitochondrial genome structure.
Journal ArticleDOI
Predominance of Duplicative VSG Gene Conversion in Antigenic Variation in African Trypanosomes
TL;DR: It is proposed that nonadapted, or pleomorphic, trypanosomes normally have an active VSGswitch mechanism, involving gene duplication that is depressed, or from which a component is absent, in monomorphic lines.