Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Tetsu Akiyama,J Ishida,Shinsaku Nakagawa,Hiroshi Ogawara,Shinya Watanabe,N Itoh,M Shibuya,Yasuo Fukami +7 more
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TLDR
Genistein inhibited the EGF-stimulated increase in phosphotyrosine level in A431 cells and scarcely inhibited the enzyme activities of serine- and threonine-specific protein kinases such as cAMP-dependent protein kinase, phosphorylase kinases, and the Ca2+/phospholipid-dependent enzymeprotein kinase C.About:
This article is published in Journal of Biological Chemistry.The article was published on 1987-04-25 and is currently open access. It has received 3761 citations till now. The article focuses on the topics: Serine/threonine-specific protein kinase & MAP2K7.read more
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The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
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The biochemistry and medical significance of the flavonoids.
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
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Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
TL;DR: A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor and interleukin-6 but not interferon gamma (IFN-gamma).
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Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor STUDY OF Lck- AND FynT-DEPENDENT T CELL ACTIVATION
Jeffrey Herbert Hanke,Joseph P. Gardner,Robert L. Dow,Paul S. Changelian,William H. Brissette,Weringer Elora Jeanne,Brian A. Pollok,Patricia A. Connelly +7 more
TL;DR: This compound offers a useful new tool for examining the role of the Lck and FynT tyrosine kinases versus ZAP-70 in T cell activation as well as the roles of other Src family kinases in receptor function.
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Tyrosine kinase inhibition: an approach to drug development
Alexander Levitzki,Aviv Gazit +1 more
TL;DR: This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
TL;DR: It is inferred that pp60src is a novel protein kinase and that the modification of proteins via the phosphorylation of tyrosine is essential to the malignant transformation of cells by Rous sarcoma virus.
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Cellular oncogenes and retroviruses
TL;DR: Role des oncogenes cellulaires dans les cellules normales, dans the transformation maligne, dan the genese des tumeurs
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Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.
TL;DR: Epidermal growth factor-enhanced protein kinase activity in plasma membrane preparations of A-431 human epidermoid carcinoma cells was shown to involve the phosphorylation of tyrosine residues, which was detected in both endogenous membrane proteins and in histone when added as an exogenous protein substrate.