A
Adam Adler
Researcher at Oklahoma Medical Research Foundation
Publications - 43
Citations - 3396
Adam Adler is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Genome-wide association study & Lupus erythematosus. The author has an hindex of 30, co-authored 37 publications receiving 2912 citations.
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Journal ArticleDOI
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.
Christopher J. Lessard,Christopher J. Lessard,He Li,He Li,Indra Adrianto,John A. Ice,Astrid Rasmussen,Kiely Grundahl,Jennifer A. Kelly,Mikhail G. Dozmorov,Corinne Miceli-Richard,Simon J. Bowman,Susan C. Lester,Per Eriksson,Maija-Leena Eloranta,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Marika Kvarnström,Helmi Jazebi,Helmi Jazebi,Deborah S. Cunninghame Graham,Martha E. Grandits,Abu N. M. Nazmul-Hossain,Ketan Patel,Adam Adler,Jacen S. Maier-Moore,Jacen S. Maier-Moore,A. Darise Farris,Michael T. Brennan,James A. Lessard,James Chodosh,Rajaram Gopalakrishnan,Kimberly S. Hefner,Glen D Houston,Andrew J.W. Huang,Pamela J. Hughes,David M Lewis,Lida Radfar,Michael D. Rohrer,Donald U. Stone,Jonathan D. Wren,Timothy J. Vyse,Patrick M. Gaffney,Judith A. James,Judith A. James,Roald Omdal,Marie Wahren-Herlenius,Gabor G. Illei,Torsten Witte,Roland Jonsson,Maureen Rischmueller,Lars Rönnblom,Gunnel Nordmark,Wan-Fai Ng,Xavier Mariette,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,R. Hal Scofield,Courtney G. Montgomery,John B. Harley,John B. Harley,Kathy L. Sivils,Kathy L. Sivils +67 more
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Journal ArticleDOI
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
Bahram Namjou,Parul H. Kothari,Jennifer A. Kelly,Stuart B. Glenn,Joshua O. Ojwang,Adam Adler,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Caroline J. Gallant,Susan A. Boackle,Lindsey A. Criswell,Robert P. Kimberly,Elizabeth E. Brown,Jeffrey C. Edberg,Anne M. Stevens,Chaim O. Jacob,Betty P. Tsao,Gary S. Gilkeson,Diane L. Kamen,Joan T. Merrill,Michelle Petri,R. R. Goldman,Luis M. Vilá,J-M Anaya,Timothy B. Niewold,Javier Martin,Bernardo A. Pons-Estel,José Mario Sabio,José Luis Callejas,Timothy J. Vyse,S-C Bae,Fred W. Perrino,Barry I. Freedman,Scofield Rh,Kathy L. Moser,Patrick M. Gaffney,Judith A. James,Carl D. Langefeld,Kenneth M. Kaufman,Kenneth M. Kaufman,John B. Harley,John P. Atkinson +42 more
TL;DR: Analysis of common TREX1 SNPs revealed a relatively common risk haplotype in European SLE patients with neurological manifestations, especially seizures, with a frequency of 58% in lupus cases compared with 45% in normal controls, and a strong association with anti-nRNP was observed.
Journal ArticleDOI
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Celi Sun,Julio E. Molineros,Loren L. Looger,Xu-jie Zhou,Kwangwoo Kim,Yukinori Okada,Jianyang Ma,Yuan-yuan Qi,Xana Kim-Howard,Prasenjeet Motghare,Krishna Bhattarai,Adam Adler,So Young Bang,Hye Soon Lee,Tae-Hwan Kim,Young Mo Kang,Chang Hee Suh,Won Tae Chung,Yong Beom Park,Jung Yoon Choe,Seung Cheol Shim,Yuta Kochi,Akari Suzuki,Michiaki Kubo,Takayuki Sumida,Kazuhiko Yamamoto,Shin-Seok Lee,Young-Jin Kim,Bok Ghee Han,Mikhail G. Dozmorov,Kenneth M. Kaufman,Jonathan D. Wren,John B. Harley,Nan Shen,Nan Shen,Kek Heng Chua,Hong Zhang,Sang Cheol Bae,Swapan K. Nath +38 more
TL;DR: Ten new SLE susceptibility loci are identified and the new loci share functional and ontological characteristics with previously reported loci and are possible drug targets for SLE therapeutics.
Journal ArticleDOI
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility
Jian Zhao,Hui Wu,Melanie Khosravi,Huijuan Cui,Xiaoxia Qian,Jennifer A. Kelly,Kenneth M. Kaufman,Kenneth M. Kaufman,Carl D. Langefeld,Adrienne H. Williams,Mary E. Comeau,Julie T. Ziegler,Miranda C. Marion,Adam Adler,Stuart B. Glenn,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Bernardo A. Pons-Estel,John B. Harley,John B. Harley,Sang Cheol Bae,So Young Bang,Soo-Kyung Cho,Chaim O. Jacob,Timothy J. Vyse,Timothy B. Niewold,Patrick M. Gaffney,Kathy L. Moser,Robert P. Kimberly,Jeffrey C. Edberg,Elizabeth E. Brown,Graciela S. Alarcón,Michelle Petri,Rosalind Ramsey-Goldman,Luis M. Vilá,John D. Reveille,Judith A. James,Judith A. James,Gary S. Gilkeson,Diane L. Kamen,Barry I. Freedman,Juan-Manuel Anaya,Joan T. Merrill,Lindsey A. Criswell,R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Anne M. Stevens,Anne M. Stevens,Joel M. Guthridge,Deh Ming Chang,Yeong Wook Song,Ji Ah Park,Eun Young Lee,Susan A. Boackle,Jennifer M. Grossman,Bevra H. Hahn,Timothy H.J. Goodship,Rita M. Cantor,Chack-Yung Yu,Nan Shen,Betty P. Tsao +61 more
TL;DR: Assessment of SNPs covering the CFH-CFHRs region suggested that the CFHR3-1Δ deletion within the SLE-associated block, but not the previously described exonic SNPs of CFH, might contribute to the development of SLE in EA, AA, and AS, providing new insights into the role of complement regulators.
Journal ArticleDOI
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus.
Amr H. Sawalha,Amr H. Sawalha,Amr H. Sawalha,Kenneth M. Kaufman,Kenneth M. Kaufman,Kenneth M. Kaufman,Jennifer A. Kelly,Adam Adler,Teresa Aberle,Jeff Kilpatrick,Edward K. Wakeland,Quan Zhen Li,Amy E. Wandstrat,David S Karp,Judith A. James,Joan T. Merrill,Joan T. Merrill,Peter E. Lipsky,John B. Harley,John B. Harley,John B. Harley +20 more
TL;DR: The findings indicate that IL-21 polymorphism is a candidate association with SLE and the functional effects of this association, when revealed, might improve the understanding of the disease and provide new therapeutic targets.