M
Marika Kvarnström
Researcher at Karolinska Institutet
Publications - 58
Citations - 1825
Marika Kvarnström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Population & Autoantibody. The author has an hindex of 19, co-authored 50 publications receiving 1304 citations. Previous affiliations of Marika Kvarnström include Karolinska University Hospital.
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Journal ArticleDOI
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.
Christopher J. Lessard,Christopher J. Lessard,He Li,He Li,Indra Adrianto,John A. Ice,Astrid Rasmussen,Kiely Grundahl,Jennifer A. Kelly,Mikhail G. Dozmorov,Corinne Miceli-Richard,Simon J. Bowman,Susan C. Lester,Per Eriksson,Maija-Leena Eloranta,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Marika Kvarnström,Helmi Jazebi,Helmi Jazebi,Deborah S. Cunninghame Graham,Martha E. Grandits,Abu N. M. Nazmul-Hossain,Ketan Patel,Adam Adler,Jacen S. Maier-Moore,Jacen S. Maier-Moore,A. Darise Farris,Michael T. Brennan,James A. Lessard,James Chodosh,Rajaram Gopalakrishnan,Kimberly S. Hefner,Glen D Houston,Andrew J.W. Huang,Pamela J. Hughes,David M Lewis,Lida Radfar,Michael D. Rohrer,Donald U. Stone,Jonathan D. Wren,Timothy J. Vyse,Patrick M. Gaffney,Judith A. James,Judith A. James,Roald Omdal,Marie Wahren-Herlenius,Gabor G. Illei,Torsten Witte,Roland Jonsson,Maureen Rischmueller,Lars Rönnblom,Gunnel Nordmark,Wan-Fai Ng,Xavier Mariette,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,R. Hal Scofield,Courtney G. Montgomery,John B. Harley,John B. Harley,Kathy L. Sivils,Kathy L. Sivils +67 more
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Journal ArticleDOI
Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium.
Pilar Brito-Zerón,Pilar Brito-Zerón,Nihan Acar-Denizli,Margit Zeher,Astrid Rasmussen,Raphaèle Seror,Elke Theander,Xiaomei Li,Chiara Baldini,Jacques-Eric Gottenberg,Debashish Danda,Luca Quartuccio,Roberta Priori,Gabriela Hernández-Molina,Aike A. Kruize,Valeria Valim,Marika Kvarnström,Damien Sène,Roberto Gerli,Sonja Praprotnik,David A. Isenberg,Roser Solans,Maureen Rischmueller,Seung Ki Kwok,Gunnel Nordmark,Yasunori Suzuki,Roberto Giacomelli,Valérie Devauchelle-Pensec,Michele Bombardieri,Benedikt Hofauer,Hendrika Bootsma,Johan G. Brun,Guadalupe Fraile,Steven E. Carsons,Tamer A. Gheita,Jacques Morel,Cristina Vollenveider,Fabiola Atzeni,Soledad Retamozo,Ildikó Horváth,Kathy L. Sivils,Thomas Mandl,Pulukool Sandhya,Salvatore De Vita,Jorge Sanchez-Guerrero,Eefje van der Heijden,Virginia Fernandes Moça Trevisani,Marie Wahren-Herlenius,Xavier Mariette,Manuel Ramos-Casals +49 more
TL;DR: This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary Sjögren's syndrome at diagnosis.
Journal ArticleDOI
Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome
Gunnel Nordmark,Gudlaug Kristjansdottir,Elke Theander,Silke Appel,Peter Eriksson,Lilian Vasaitis,Marika Kvarnström,Nicolas Delaleu,Per Lundmark,Anders Lundmark,Christopher Sjöwall,Johan G. Brun,Johan G. Brun,Malin V. Jonsson,Erna Harboe,Lasse G. Gøransson,Svein Joar Auglænd Johnsen,Peter Söderkvist,Maija-Leena Eloranta,Gunnar V. Alm,Eva Baecklund,Marie Wahren-Herlenius,Roald Omdal,Lars Rönnblom,Roland Jonsson,Ann-Christine Syvänen +25 more
TL;DR: In this paper, the authors performed a candidate gene association study in 540 patients with primary Sjogren's Syndrome (SS) from Sweden (n = 344) and Norway (N = 196) and 532 controls (n= 319 Swedish, n = 213 Norwegian).
Journal Article
How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).
Pilar Brito-Zerón,Nihan Acar-Denizli,Wan-Fai Ng,Margit Zeher,Astrid Rasmussen,Thomas Mandl,Raphaèle Seror,Xiaomei Li,Chiara Baldini,Jacques-Eric Gottenberg,Debashish Danda,Luca Quartuccio,Roberta Priori,Gabriela Hernández-Molina,Berkan Armagan,Aike A. Kruize,Seung-Ki Kwok,Marika Kvarnström,Sonja Praprotnik,Damien Sène,Elena Bartoloni,Roser Solans,Maureen Rischmueller,Yasunori Suzuki,David A. Isenberg,Valeria Valim,Piotr Wiland,Gunnel Nordmark,Guadalupe Fraile,Hendrika Bootsma,Takashi Nakamura,Roberto Giacomelli,Valérie Devauchelle-Pensec,Andreas Knopf,Michele Bombardieri,Virginia-Fernandes Trevisani,Daniel Hammenfors,Sandra Gofinet Pasoto,Soledad Retamozo,Tamer A. Gheita,Fabiola Atzeni,Jacques Morel,Cristina Vollenveider,Ildiko-Fanny Horvath,Kathy L. Sivils,Peter Olsson,Salvatore De Vita,Jorge Sánchez-Guerrero,Levent Kilic,Marie Wahren-Herlenius,Xavier Mariette,Manuel Ramos-Casals +51 more
TL;DR: The strong influence of immunological markers on the phenotype of primary SjS at diagnosis is confirmed in the largest multi-ethnic international cohort ever analysed, with a greater influence for cryoglobulinaemic-related markers in comparison with Ro/La autoantibodies and ANA.
Journal ArticleDOI
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
Leah C. Kottyan,Erin E. Zoller,Jessica Bene,Xiaoming Lu,Jennifer A. Kelly,Andrew M. Rupert,Christopher J. Lessard,Samuel E. Vaughn,Miranda C. Marion,Matthew T. Weirauch,Bahram Namjou,Adam Adler,Astrid Rasmussen,Stuart B. Glenn,Courtney G. Montgomery,Gideon M. Hirschfield,Gang Xie,Catalina Coltescu,Christopher I. Amos,He Li,John A. Ice,Swapan K. Nath,Xavier Mariette,Simon J Bowman,Maureen Rischmueller,Susan C. Lester,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Roald Omdal,Deborah S. Cunninghame-Graham,Timothy J. Vyse,Corinne Miceli-Richard,Michael T. Brennan,James A. Lessard,Marie Wahren-Herlenius,Marika Kvarnström,Gabor G. Illei,Torsten Witte,Roland Jonsson,Per Eriksson,Gunnel Nordmark,Wan-Fai Ng,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,Joan T. Merrill,Judith A. James,Joel M. Guthridge,R. Hal Scofield,Marta E. Alarcón-Riquelme,Sang Cheol Bae,Susan A. Boackle,Lindsey A. Criswell,Gary S. Gilkeson,Diane L. Kamen,Chaim O. Jacob,Robert P. Kimberly,Elizabeth E. Brown,Jeffrey C. Edberg,Graciela S. Alarcón,John D. Reveille,Luis M. Vilá,Michelle Petri,Rosalind Ramsey-Goldman,Barry I. Freedman,Timothy B. Niewold,Anne M. Stevens,Betty P. Tsao,Jun Ying,Maureen D. Mayes,Olga Y. Gorlova,Ward Wakeland,Timothy R D J Radstake,E. Martin,Javier Martin,Katherine A. Siminovitch,Kathy L. Sivils,Patrick M. Gaffney,Carl D. Langefeld,John B. Harley,Kenneth M. Kaufman +81 more
TL;DR: Both SLE elements of the statistical model appear to operate in Sjögren's syndrome and systemic sclerosis whereas only the IRF5-TNPO3 gene-spanning haplotype is associated with primary biliary cirrhosis, demonstrating the nuance of similarity and difference in autoimmune disease risk mechanisms at IRF 5- TNPO3.