S
Sita J. Saunders
Researcher at University of Freiburg
Publications - 14
Citations - 2286
Sita J. Saunders is an academic researcher from University of Freiburg. The author has contributed to research in topics: CRISPR & CRISPR Loci. The author has an hindex of 9, co-authored 12 publications receiving 1816 citations. Previous affiliations of Sita J. Saunders include University of Copenhagen.
Papers
More filters
Journal ArticleDOI
An updated evolutionary classification of CRISPR–Cas systems
Kira S. Makarova,Yuri I. Wolf,Omer S. Alkhnbashi,Fabrizio Costa,Shiraz A. Shah,Sita J. Saunders,Rodolphe Barrangou,Stan J. J. Brouns,Emmanuelle Charpentier,Daniel H. Haft,Philippe Horvath,Sylvain Moineau,Francisco J. M. Mojica,Rebecca M. Terns,Michael P. Terns,Malcolm F. White,Alexander F. Yakunin,Roger A. Garrett,John van der Oost,Rolf Backofen,Eugene V. Koonin +20 more
TL;DR: An approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR–cas loci into distinct classes, types and subtypes is presented.
Journal ArticleDOI
CRISPRstrand: predicting repeat orientations to determine the crRNA-encoding strand at CRISPR loci
Omer S. Alkhnbashi,Fabrizio Costa,Shiraz A. Shah,Roger A. Garrett,Sita J. Saunders,Rolf Backofen +5 more
TL;DR: A fast and accurate tool to determine the crRNA-encoding strand at CRISPR loci by predicting the correct orientation of repeats based on an advanced machine learning approach is presented.
Journal ArticleDOI
Characterizing leader sequences of CRISPR loci
Omer S. Alkhnbashi,Shiraz A. Shah,Roger A. Garrett,Sita J. Saunders,Fabrizio Costa,Rolf Backofen +5 more
TL;DR: A method to successfully detect leader sequences by focusing on the consensus repeat of the adjacent CRISPR array and weak upstream conservation signals is developed and identified several characteristic properties of leader sequences specific to archaea and bacteria, ranging from distinctive sizes to preferential indel localization.
Journal ArticleDOI
Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells
Martin Hölzer,Verena Krähling,Fabian Amman,Emanuel Barth,Emanuel Barth,Stephan H. Bernhart,Victor Adriano Okstoft Carmelo,Maximilian Collatz,Maximilian Collatz,Gero Doose,Florian Eggenhofer,Florian Eggenhofer,Jan Ewald,Jörg Fallmann,Lasse Feldhahn,Lasse Feldhahn,Markus Fricke,Juliane Gebauer,Andreas J. Gruber,Franziska Hufsky,Henrike Indrischek,Sabina Kanton,Jörg Linde,Nelly Mostajo,Nelly Mostajo,Roman Ochsenreiter,Konstantin Riege,Lorena Rivarola-Duarte,Lorena Rivarola-Duarte,Abdullah H. Sahyoun,Sita J. Saunders,Stefan E. Seemann,Andrea Tanzer,Bertram Vogel,Bertram Vogel,Stefanie Wehner,Stefanie Wehner,Michael T. Wolfinger,Michael T. Wolfinger,Rolf Backofen,Rolf Backofen,Jan Gorodkin,Ivo Grosse,Ivo Grosse,Ivo L. Hofacker,Ivo L. Hofacker,Steve Hoffmann,Christoph Kaleta,Peter F. Stadler,Peter F. Stadler,Stephan Becker,Manja Marz,Manja Marz +52 more
TL;DR: It is demonstrated that the replication of filoviruses is more rapid in human cells than in bat cells, and the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors.
Journal ArticleDOI
Structural constraints and enzymatic promiscuity in the Cas6-dependent generation of crRNAs.
Viktoria Reimann,Omer S. Alkhnbashi,Sita J. Saunders,Ingeborg Scholz,Stephanie Hein,Rolf Backofen,Wolfgang R. Hess +6 more
TL;DR: It is concluded that the cleavage of CRISPR1 andCRISPR2 repeat instances requires a stable formation of the characteristic hairpin motif, which is similar between the two types of repeats.