Spyros Pournaras

TL;DR: Genomic and genetic studies have elucidated the role of mobile genetic elements in the transfer of antibiotic resistance genes and substantiate the rate of genetic alterations associated with acquisition in A. baumannii of various resistance genes, including OXA- and metallo-β-lactamase-type carbapenemase genes.

TL;DR: Outcomes, risk factors for mortality and impact of appropriate antimicrobial treatment in patients with BSIs caused by molecularly confirmed KPC-KP were investigated, finding appropriate treatment is the only modifiable independent predictor of infection outcome.

TL;DR: Patients with BSIs due to CPE should receive active therapy as soon as they are diagnosed, and monotherapy should be considered for those in the low-mortality-score stratum.

TL;DR: Criteria must be established for which isolates should be suspected and screened for carbapenemase production, and for which tests (phenotypic and/or genotypic) should be adopted for confirmation of the resistance mechanism, and strategies should be devised for surveillance of carbapanemase producers in order to enable the implementation of effective surveillance programmes.

TL;DR: Resistance to imipenem and meropenem was observed in 211 isolates of Pseudomonas aeruginosa recovered in a Greek university hospital during 1996 to 1998 and high-level resistance to both carbapenems was associated with production of the class B β-lactamase VIM-1.