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Stefan Costinean
Researcher at Ohio State University
Publications - 47
Citations - 8666
Stefan Costinean is an academic researcher from Ohio State University. The author has contributed to research in topics: Cancer & microRNA. The author has an hindex of 32, co-authored 44 publications receiving 8075 citations. Previous affiliations of Stefan Costinean include Thomas Jefferson University & University of Nebraska Medical Center.
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Journal ArticleDOI
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Muller Fabbri,Ramiro Garzon,Amelia Cimmino,Amelia Cimmino,Zhongfa Liu,Nicola Zanesi,Elisa Callegari,Shujun Liu,Hansjuerg Alder,Stefan Costinean,Cecilia Fernandez-Cymering,Stefano Volinia,Gulnur Guler,Carl Morrison,Kenneth K. Chan,Guido Marcucci,George A. Calin,Kay Huebner,Carlo M. Croce +18 more
TL;DR: The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo.
Journal ArticleDOI
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock
Esmerina Tili,Jean-Jacques Michaille,Jean-Jacques Michaille,Amelia Cimino,Stefan Costinean,Calin Dan Dumitru,Brett Adair,Muller Fabbri,Hannes Alder,Chang Gong Liu,George A. Calin,Carlo M. Croce +11 more
TL;DR: The data suggest that the LPS/TNF-α-dependent regulation of miR-155 and miR -125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design.
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miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.
Michela Garofalo,Gianpiero Di Leva,Giulia Romano,Gerard J. Nuovo,Sung-Suk Suh,Apollinaire Ngankeu,Cristian Taccioli,Flavia Pichiorri,Hansjuerg Alder,Paola Secchiero,Pierluigi Gasparini,Arianna Gonelli,Stefan Costinean,Mario Acunzo,Gerolama Condorelli,Carlo M. Croce +15 more
TL;DR: It is reported that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells, and it is demonstrated that the MET oncogene is involved in miR+222 activation through the c-Jun transcription factor.
Journal ArticleDOI
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
Shu-Hao Hsu,Bo Wang,Janaiah Kota,Jianhua Yu,Stefan Costinean,Huban Kutay,Lianbo Yu,Shoumei Bai,Shoumei Bai,Krista M. D. La Perle,Raghu R. Chivukula,Hsiaoyin Mao,Min Wei,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Michael A. Caligiuri,Samson T. Jacob,Joshua T. Mendell,Kalpana Ghoshal +20 more
TL;DR: It is demonstrated that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC, demonstrating critical functions for miR-122 in the maintenance of liver homeostasis and have important therapeutic implications, including the potential utility of mi R-122 delivery for selected patients with HCC and the need for careful monitoring of patients receiving miR -122 inhibition therapy for HCV.
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microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer.
Chiara Braconi,Takayuki Kogure,Takayuki Kogure,Nicola Valeri,Nianyuan Huang,Gerard J. Nuovo,Stefan Costinean,Massimo Negrini,Elena Miotto,Carlo M. Croce,Tushar Patel,Tushar Patel +11 more
TL;DR: Data show that methylation-dependent tissue-specific regulation of the lncRNA MEG3 by miR-29a may contribute to HCC growth and highlight the inter-relationship between two classes of non-coding RNA, miRNAs and lncRNAs, and epigenetic regulation of gene expression.