S
Stephan Rust
Researcher at Leibniz Association
Publications - 3
Citations - 683
Stephan Rust is an academic researcher from Leibniz Association. The author has contributed to research in topics: Genome-wide association study & ABCG1. The author has an hindex of 3, co-authored 3 publications receiving 623 citations.
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Journal ArticleDOI
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
John F. Peden,Jemma C. Hopewell,Danish Saleheen,John C. Chambers,Jorg Hager,Nicole Soranzo,Rory Collins,John Danesh,Paul Elliott,Martin Farrall,Kathy Stirrups,Weihua Zhang,Anders Hamsten,Anders Hamsten,Sarah Parish,Mark Lathrop,Hugh Watkins,Robert Clarke,Panos Deloukas,Jaspal S. Kooner,Anuj Goel,Halit Ongen,Rona J. Strawbridge,Rona J. Strawbridge,Simon Heath,Anders Mälarstig,Anders Mälarstig,Anna Helgadottir,John Öhrvik,John Öhrvik,Muhammed Murtaza,Simon C. Potter,Sarah E. Hunt,Marc Delepine,Shapour Jalilzadeh,Tomas Axelsson,Ann-Christine Syvänen,Rhian Gwilliam,Suzannah Bumpstead,Emma Gray,Sarah Edkins,Lasse Folkersen,Lasse Folkersen,Theodosios Kyriakou,Anders Franco-Cereceda,Anders Gabrielsen,Udo Seedorf,Per Eriksson,Per Eriksson,Alison Offer,Louise Bowman,Peter Sleight,Jane Armitage,Richard Peto,Gonçalo R. Abecasis,Nabeel Ahmed,Mark J. Caulfield,Peter Donnelly,Philippe Froguel,Angad S. Kooner,Mark I. McCarthy,Nilesh J. Samani,James Scott,Joban Sehmi,Angela Silveira,Angela Silveira,Mai-Lis Hellénius,Ferdinand M. van't Hooft,Ferdinand M. van't Hooft,Gunnar O Olsson,Stephan Rust,Gerd Assmann,Simona Barlera,Gianni Tognoni,Maria Grazia Franzosi,Pamela Linksted,Fiona Green,Asif Rasheed,Moazzam Zaidi,Nabi Shah,Maria Samuel,Nadeem Hayat Mallick,Muhammad Azhar,Khan Shah Zaman,Abdus Samad,M. Ishaq,Ali Raza Gardezi,Fazal-ur-Rehman Memon,Philippe M. Frossard,Tim D. Spector,Leena Peltonen,Leena Peltonen,Markku S. Nieminen,Juha Sinisalo,Veikko Salomaa,Samuli Ripatti,Derrick A Bennett,Karin Leander,Bruna Gigante,Ulf de Faire,Silvia Pietri,Francesca Gori,Roberto Marchioli,Suthesh Sivapalaratnam,John J.P. Kastelein,Mieke D. Trip,Eirini V. Theodoraki,George V. Dedoussis,Engert Jc,Salim Yusuf,Sonia S. Anand +110 more
TL;DR: Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD(8) as mentioned in this paper.
Journal ArticleDOI
Characterization of Cholesterol Homeostasis in Telomerase-immortalized Tangier Disease Fibroblasts Reveals Marked Phenotype Variability
Frank Kannenberg,Kerstin Gorzelniak,Kathrin Jäger,Manfred Fobker,Stephan Rust,Joyce J. Repa,Michael G. Roth,Ingemar Björkhem,Michael Walter +8 more
TL;DR: The data support the contention that side chain-oxidized oxysterols are strong suppressors of cholesterol biosynthesis under specific pathological conditions in humans and demonstrate the usefulness of telomerase-immortalized cells in studying this cellular phenotype.
Journal ArticleDOI
3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency
Thomas Engel,Manfred Fobker,Jana Buchmann,Frank Kannenberg,Stephan Rust,Jerzy-Roch Nofer,Annette Schürmann,Udo Seedorf +7 more
TL;DR: The results suggest that 25-HC and CT are physiologic substrates for ABCG1, and excessive accumulation of these oxysterols may explain the increased rate of cell death and the inflammatory phenotype observed in Abcg1-deficient animals and cells.