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Salim Yusuf
Researcher at McMaster University
Publications - 6
Citations - 1190
Salim Yusuf is an academic researcher from McMaster University. The author has contributed to research in topics: Discovery and development of direct thrombin inhibitors & Genome-wide association study. The author has an hindex of 5, co-authored 6 publications receiving 1100 citations. Previous affiliations of Salim Yusuf include Hamilton General Hospital & Population Health Research Institute.
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Journal ArticleDOI
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
John F. Peden,Jemma C. Hopewell,Danish Saleheen,John C. Chambers,Jorg Hager,Nicole Soranzo,Rory Collins,John Danesh,Paul Elliott,Martin Farrall,Kathy Stirrups,Weihua Zhang,Anders Hamsten,Anders Hamsten,Sarah Parish,Mark Lathrop,Hugh Watkins,Robert Clarke,Panos Deloukas,Jaspal S. Kooner,Anuj Goel,Halit Ongen,Rona J. Strawbridge,Rona J. Strawbridge,Simon Heath,Anders Mälarstig,Anders Mälarstig,Anna Helgadottir,John Öhrvik,John Öhrvik,Muhammed Murtaza,Simon C. Potter,Sarah E. Hunt,Marc Delepine,Shapour Jalilzadeh,Tomas Axelsson,Ann-Christine Syvänen,Rhian Gwilliam,Suzannah Bumpstead,Emma Gray,Sarah Edkins,Lasse Folkersen,Lasse Folkersen,Theodosios Kyriakou,Anders Franco-Cereceda,Anders Gabrielsen,Udo Seedorf,Per Eriksson,Per Eriksson,Alison Offer,Louise Bowman,Peter Sleight,Jane Armitage,Richard Peto,Gonçalo R. Abecasis,Nabeel Ahmed,Mark J. Caulfield,Peter Donnelly,Philippe Froguel,Angad S. Kooner,Mark I. McCarthy,Nilesh J. Samani,James Scott,Joban Sehmi,Angela Silveira,Angela Silveira,Mai-Lis Hellénius,Ferdinand M. van't Hooft,Ferdinand M. van't Hooft,Gunnar O Olsson,Stephan Rust,Gerd Assmann,Simona Barlera,Gianni Tognoni,Maria Grazia Franzosi,Pamela Linksted,Fiona Green,Asif Rasheed,Moazzam Zaidi,Nabi Shah,Maria Samuel,Nadeem Hayat Mallick,Muhammad Azhar,Khan Shah Zaman,Abdus Samad,M. Ishaq,Ali Raza Gardezi,Fazal-ur-Rehman Memon,Philippe M. Frossard,Tim D. Spector,Leena Peltonen,Leena Peltonen,Markku S. Nieminen,Juha Sinisalo,Veikko Salomaa,Samuli Ripatti,Derrick A Bennett,Karin Leander,Bruna Gigante,Ulf de Faire,Silvia Pietri,Francesca Gori,Roberto Marchioli,Suthesh Sivapalaratnam,John J.P. Kastelein,Mieke D. Trip,Eirini V. Theodoraki,George V. Dedoussis,Engert Jc,Salim Yusuf,Sonia S. Anand +110 more
TL;DR: Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD(8) as mentioned in this paper.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
Folkert W. Asselbergs,Yiran Guo,Yiran Guo,Erik P A Van Iperen,Suthesh Sivapalaratnam,Vinicius Tragante,Matthew B. Lanktree,Leslie A. Lange,Berta Almoguera,Yolande Appelman,John Barnard,Jens Baumert,Amber L. Beitelshees,Tushar Bhangale,Yii-Der Ida Chen,Tom R. Gaunt,Yan Gong,Jemma C. Hopewell,Toby Johnson,Marcus E. Kleber,Taimour Y. Langaee,Mingyao Li,Yun Li,Kiang Liu,Caitrin W. McDonough,Matthijs F.L. Meijs,Rita P.S. Middelberg,Kiran Musunuru,Kiran Musunuru,Christopher P. Nelson,Jeffery R. O'Connell,Sandosh Padmanabhan,James S. Pankow,Nathan Pankratz,Suzanne Rafelt,Ramakrishnan Rajagopalan,Simon P. R. Romaine,Nicholas J. Schork,Jonathan A. Shaffer,Haiqing Shen,Erin N. Smith,Sam E. Tischfield,Peter J. van der Most,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Kelly A. Volcik,Li Zhang,Kent R. Bailey,Kristian M. Bailey,Florianne Bauer,Jolanda M. A. Boer,Peter S. Braund,Amber A. Burt,Paul Burton,Sarah G. Buxbaum,Wei Chen,Rhonda M. Cooper-DeHoff,L. Adrienne Cupples,L. Adrienne Cupples,Jonas S. Dejong,Christian Delles,David Duggan,Myriam Fornage,Clement E. Furlong,Nicole L. Glazer,John G. Gums,Claire E. Hastie,Michael V. Holmes,Thomas Illig,Susan Kirkland,Mika Kivimäki,Ronald Klein,Barbara E.K. Klein,Charles Kooperberg,Kandice Kottke-Marchant,Meena Kumari,Andrea Z. LaCroix,Laya Mallela,Gurunathan Murugesan,Jose M. Ordovas,Willem H. Ouwehand,Wendy S. Post,Richa Saxena,Richa Saxena,Hubert Scharnagl,Pamela J. Schreiner,Tina Shah,Denis C. Shields,Daichi Shimbo,Sathanur R. Srinivasan,Ronald P. Stolk,Daniel I. Swerdlow,Herman A. Taylor,Eric J. Topol,Elina Toskala,Joost L. Van Pelt,Jessica van Setten,Salim Yusuf,John C. Whittaker,John C. Whittaker,A. H. Zwinderman,Sonia S. Anand,Anthony J. Balmforth,Gerald S. Berenson,Connie R. Bezzina,Connie R. Bezzina,Bernhard O. Boehm,Eric Boerwinkle,Juan P. Casas,Juan P. Casas,Mark J. Caulfield,Robert Clarke,John M. C. Connell,Karen J. Cruickshanks,Karina W. Davidson,Ian N. M. Day,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Pieter A. Doevendans,Anna F. Dominiczak,Alistair S. Hall,Catharina A. Hartman,Christian Hengstenberg,Hans L. Hillege,Marten H. Hofker,Steve E. Humphries,Gail P. Jarvik,Julie A. Johnson,Bernhard M. Kaess,Sekar Kathiresan,Sekar Kathiresan,Wolfgang Koenig,Debbie A Lawlor,Winfried März,Winfried März,Olle Melander,Braxton D. Mitchell,Grant W. Montgomery,Patricia B. Munroe,Sarah S. Murray,Stephen Newhouse,N. Charlotte Onland-Moret,Neil R Poulter,Bruce M. Psaty,Bruce M. Psaty,Susan Redline,Stephen S. Rich,Jerome I. Rotter,Heribert Schunkert,Peter Sever,Alan R. Shuldiner,Alan R. Shuldiner,Roy L. Silverstein,Alice V. Stanton,Alice V. Stanton,Barbara Thorand,Mieke D. Trip,Michael Y. Tsai,Pim van der Harst,Ellen Van Der Schoot,Yvonne T. van der Schouw,W. M. Monique Verschuren,Hugh Watkins,Arthur A.M. Wilde,Bruce H. R. Wolffenbuttel,John Whitfield,G. Kees Hovingh,Christie M. Ballantyne,Cisca Wijmenga,Muredach P. Reilly,Nicholas G. Martin,James G. Wilson,Daniel J. Rader,Nilesh J. Samani,Nilesh J. Samani,Alexander P. Reiner,Robert A. Hegele,John J.P. Kastelein,Aroon D. Hingorani,Philippa J. Talmud,Hakon Hakonarson,Clara C. Elbers,Brendan J. Keating,Fotios Drenos +184 more
TL;DR: This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
Journal ArticleDOI
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients'data
Salim Yusuf,Christopher B. Granger,John W. Eikelboom,Shamir R. Mehta,J Pogue,P Tait,S Behar,M Benderly,Hanoch Hod,E Kaplinsky,N Barrett,R Bilke,M Luz,M Marhoefer,L Roi,D Trenery,John A. Bittl,H Boersma,Marcus Flather,Colin Baigent,Maarten L. Simoons,Robert M. Califf,Karen S. Pieper,Eric J. Topol,Jeff Weitz,Patrick W. Serruys,Harvey D. White,Karl-Ludwig Neuhaus,Uwe Zeymer,John Simes,P Close,Susan Edwards,P Gallo,M Henis,Sonia S. Anand,W Kimball,C Meanwell,J Villiger,Elliott M. Antman,Eugene Braunwald,Michael F. Gibson,Sean P. Murphy,Lars Grip,Peter Held,Trialist Dti. +44 more
TL;DR: Direct thrombin inhibitors are superior to heparin for the prevention of death or myocardial infarction in patients with acute coronary syndromes, and this information should prompt further clinical development of direct throm bin inhibitors for the management of arterial thrombosis.
Journal ArticleDOI
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations
Sachiko Yoneyama,Yiran Guo,Yiran Guo,Matthew B. Lanktree,Michael R. Barnes,Michael R. Barnes,Clara C. Elbers,Konrad J. Karczewski,Sandosh Padmanabhan,Florianne Bauer,Jens Baumert,Amber L. Beitelshees,Gerald S. Berenson,Jolanda M. A. Boer,Gregory L. Burke,Brian E. Cade,Wei Chen,Rhonda M. Cooper-DeHoff,Tom R. Gaunt,Christian Gieger,Yan Gong,Mathias Gorski,Nancy L. Heard-Costa,Toby Johnson,Michael J. LaMonte,Caitrin W. McDonough,Keri L. Monda,Keri L. Monda,N. Charlotte Onland-Moret,Christopher P. Nelson,Christopher P. Nelson,Jeffrey R. O'Connell,Jose M. Ordovas,Inga Peter,Annette Peters,Jonathan A. Shaffer,Haiqinq Shen,Erin N. Smith,Liz Speilotes,Liz Speilotes,Liz Speilotes,Fridtjof Thomas,Barbara Thorand,W. M. Monique Verschuren,Sonia S. Anand,Sonia S. Anand,Anna F. Dominiczak,Karina W. Davidson,Robert A. Hegele,Iris M. Heid,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Julie A. Johnson,Susan Kirkland,Wolfgang König,Taimour Y. Langaee,Jeanne M. McCaffery,Jeanne M. McCaffery,Olle Melander,Braxton D. Mitchell,Patricia B. Munroe,Sarah S. Murray,George J. Papanicolaou,Susan Redline,Muredach P. Reilly,Nilesh J. Samani,Nilesh J. Samani,Nicholas J. Schork,Nicholas J. Schork,Yvonne T. van der Schouw,Daichi Shimbo,Alan R. Shuldiner,Alan R. Shuldiner,Martin D. Tobin,Cisca Wijmenga,Salim Yusuf,Salim Yusuf,Hakon Hakonarson,Leslie A. Lange,Ellen W. Demerath,Caroline S. Fox,Kari E. North,Alexander P. Reiner,Brendan J. Keating,Kira C. Taylor +85 more
TL;DR: Functional analysis using ENCODE and eQTL databases revealed that several of these loci are in regulatory regions or regions with differential expression in adipose tissue, supporting an already established sexual dimorphism of central adiposity-related genetic variants.
Journal ArticleDOI
Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention.
Peter Sinnaeve,John Simes,Salim Yusuf,Jyotsna Garg,Shamir R. Mehta,John W. Eikelboom,John A. Bittl,Patrick W. Serruys,Eric J. Topol,Christopher B. Granger +9 more
TL;DR: After adjustment for baseline differences and propensity to undergo early PCI, DTIs appeared to be more effective than heparin in reducing death or re-infarction among patients undergoing early PCI.